Universidade Federal de Santa Maria

About: Universidade Federal de Santa Maria is a education organization based out in Santa Maria, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 21178 authors who have published 35632 publications receiving 371665 citations.

Evidence that l -Carnitine and Selenium Supplementation Reduces Oxidative Stress in Phenylketonuric Patients

Abstract: It is well established that the involvement of reactive species in the pathophysiology of several neurological diseases, including phenylketonuria (PKU), a metabolic genetic disorder biochemically characterized by elevated levels of phenylalanine (Phe). In previous studies, we verified that PKU patients (treated with a protein-restricted diet supplemented with a special formula not containing l-carnitine and selenium) presented high lipid and protein oxidative damage as well as a reduction of antioxidants when compared to the healthy individuals. Our goal in the present study was to evaluate the effect of Phe-restricted diet supplemented with l-carnitine and selenium, two well-known antioxidant compounds, on oxidative damage in PKU patients. We investigated various oxidative stress parameters in blood of 18 treated PKU patients before and after 6 months of supplementation with a special formula containing l-carnitine and selenium. It was verified that treatment with l-carnitine and selenium was capable of reverting the lipid peroxidation, measured by thiobarbituric acid-reactive species, and the protein oxidative damage, measured by sulfhydryl oxidation, to the levels of controls. Additionally, the reduced activity of glutathione peroxidase was normalized by the antioxidant supplementation. It was also verified a significant inverse correlation between lipid peroxidation and l-carnitine blood levels as well as a significant positive correlation between glutathione peroxidase activity and blood selenium concentration. In conclusion, our results suggest that supplementation of l-carnitine and selenium is important for PKU patients since it could help to correct the oxidative stress process which possibly contributes, at least in part, to the neurological symptoms found in phenylketonuric patients.

Sliding Mode Controller in a Multiloop Framework for a Grid-Connected VSI With LCL Filter

Abstract: This paper proposes a multiloop framework for current control of grid-connected voltage source inverters (VSIs) with LCL output filter. The discrete-time model is of third-order with a nonminimum phase zero when controlling the grid side current. This poses some difficulties on the design of most types of controllers. Motivated by this problem, the inner loop is implemented by a discrete-time sliding mode control law to ensure the tracking of the converter side current. This can be achieved regardless the grid impedance and voltage, making the converter to behave like a current source inverter with a capacitive+inductive ( CL ) filter. Thus, the problem of current control falls from a third-order system to a second-order system. Several types of controllers can be designed to implement the outer loop based on the equivalent CL circuit. In this work, a resonant controller with a virtual resistor was applied. Simulations and experimental results are presented to validate the proposal.