Institution
Universidade Federal de Santa Maria
Education•Santa Maria, Brazil•
About: Universidade Federal de Santa Maria is a education organization based out in Santa Maria, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 21178 authors who have published 35632 publications receiving 371665 citations.
Papers published on a yearly basis
Papers
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TL;DR: The present results showed that, in 96 h, glyphosate changed toxicological parameters analyzed in piava, and herbicide exposure increased protein and carbohydrate levels of the mucus layer at all tested concentrations.
Abstract: In recent years, commercial glyphosate herbicide formulations have been widely used in agriculture to control aquatic weeds These pesticides may result in disruption of ecological balance, causing damage to nontarget organisms including fish Teleostean fish (Leporinus obtusidens) were exposed to commercial glyphosate herbicide formulation at 0 (control), 3, 6, 10 or 20 mg L−1 for 96 h The effects of herbicide on plasmatic metabolic parameters, thiobarbituric acid reactive substances (TBARS), catalase activity, protein carbonyl, and mucus layer parameters were studied Plasmatic glucose and lactate levels increased but protein levels showed reduction after herbicide exposure TBARS levels in brain showed a reduction at all tested concentrations However, liver demonstrated increased TBARS levels at all tested concentrations, whereas in white muscle TBARS production did not change after exposure to herbicide Fish exposed to all concentrations of glyphosate showed increase in liver catalase activity and protein carbonyl Herbicide exposure increased protein and carbohydrate levels of the mucus layer at all tested concentrations The present results showed that, in 96 h, glyphosate changed toxicological parameters analyzed in piava Parameters measured in this study may be useful in environmental biomonitoring
81 citations
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TL;DR: The results obtained in this study showed that T. catharinensis has antimicrobial and anti-herpetic activities and that these properties are reported for the first time for this species.
81 citations
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TL;DR: Direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety is focused on and different opinions that exist in this field are discussed, highlighting the importance of oxidative Stress in the etiology, incidence, progression, and prevention of psychiatric disorders.
Abstract: Oxidative stress caused by reactive species, including reactive oxygen species, reactive nitrogen species, and unbound, adventitious metal ions (e.g., iron [Fe] and copper [Cu]), is an underlying cause of various neurodegenerative diseases. These reactive species are an inevitable by-product of cellular respiration or other metabolic processes that may cause the oxidation of lipids, nucleic acids, and proteins. Oxidative stress has recently been implicated in depression and anxiety-related disorders. Furthermore, the manifestation of anxiety in numerous psychiatric disorders, such as generalized anxiety disorder, depressive disorder, panic disorder, phobia, obsessive-compulsive disorder, and posttraumatic stress disorder, highlights the importance of studying the underlying biology of these disorders to gain a better understanding of the disease and to identify common biomarkers for these disorders. Most recently, the expression of glutathione reductase 1 and glyoxalase 1, which are genes involved in antioxidative metabolism, were reported to be correlated with anxiety-related phenotypes. This review focuses on direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety and discusses different opinions that exist in this field. Antioxidant therapeutic strategies are also discussed, highlighting the importance of oxidative stress in the etiology, incidence, progression, and prevention of psychiatric disorders.
81 citations
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TL;DR: In this paper, a highly efficient and reusable zeolite was prepared using the biopolymer chitin as mesoporosity agent and applied to adsorb three cationic dyes.
81 citations
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TL;DR: The results indicate that (PhSe)(2) elicited significant antidepressant-like and anxiolytic-like effects and seems to involve an interaction with L-arginine-NO-cGMP pathway.
Abstract: This study investigated the possible antidepressant-like and anxiolytic-like effects of diphenyl diselenide, (PhSe)(2) in mice. The involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the antidepressant-like effect was also evaluated. The immobility times in the tail suspension test (TST) and forced swimming test (FST) were reduced by (PhSe)(2) (5-100 mg/kg; oral route, p.o.). The antiimmobility effect of (PhSe)(2) (5 mg/kg, p.o.) in the TST was prevented by pretreatment of mice with L-arginine [a substrate for nitric oxide synthase (NOS)], methylene blue [an inhibitor of NO synthase and sGC] and sildenafil [a phosphodiesterase 5 inhibitor]. Furthermore, a sub-effective dose of (PhSe)(2) (0.1 mg/kg, p.o.) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine [L-NNA; 0.3mg/kg, i.p. inhibitor of NOS], (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ; 30 pmol/site i.c.v., a specific inhibitor of soluble guanylate cyclase (sGC)], fluoxetine and imipramine in the TST. (PhSe)(2) (50-100 mg/kg, p.o.) induced anxiolytic-like effect in the elevated plus-maze test and light/dark box. Together the results indicate that (PhSe)(2) elicited significant antidepressant-like and anxiolytic-like effects. The antidepressant-like action caused by (PhSe)(2) seems to involve an interaction with L-arginine-NO-cGMP pathway.
80 citations
Authors
Showing all 21330 results
Name | H-index | Papers | Citations |
---|---|---|---|
João Rocha | 93 | 1521 | 49472 |
Jose Rodriguez | 93 | 803 | 58176 |
Christian C. Abnet | 86 | 413 | 29165 |
Thaisa Storchi-Bergmann | 70 | 318 | 22817 |
Ali Emadi | 69 | 660 | 24174 |
Luis S. Pereira | 68 | 317 | 35582 |
Diogo O. Souza | 68 | 534 | 17793 |
Adair R.S. Santos | 63 | 329 | 14529 |
Ahmad Awada | 61 | 547 | 16109 |
Farin Kamangar | 61 | 237 | 16554 |
Stefan Laufer | 59 | 481 | 11158 |
Cristina W. Nogueira | 59 | 503 | 16655 |
Ana Lúcia S. Rodrigues | 58 | 244 | 10187 |
Julia F. Ridpath | 57 | 229 | 9543 |
Ludger A. Wessjohann | 53 | 513 | 11405 |