Université Nantes Angers Le Mans

About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Finite element method. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.

Use of Vitamin K Antagonists and Brain Volumetry in Older Adults: Preliminary Results From the GAIT Study

Abstract: generally considered safe, they have some adverse effects, so their prescription must always be based on major available scientific evidence. This study confirms that PPIs are frequently prescribed without an appropriate indication, and a trend of overprescription and not underprescription was observed. It was attempted to determine the characteristics of individuals at higher risk of inappropriate PPI prescription. Age does not affect PPI appropriateness; a similar percentage of PPI inappropriateness was observed in different age groups. Similar results were found previously. The CIRS comorbidity index was not associated with inappropriate PPI prescription, in contrast to the previous study, which found a statistically significant association between these two factors. The current study found an increasing trend in wrong PPI prescription with increasing number of drugs taken daily. The association was not statistically significant, but a larger study might validate this. In conclusion, the chronic use of PPIs seems to have a high margin of safety, but doubts have been raised about possible risks associated with their long-term use. Greater attention must be paid to protect people from unnecessary adverse drug effects and to cut healthcare costs.

State Machine for Detecting Vehicles by Magnetometer Sensors

Abstract: This letter presents a vehicle detection state machine for magnetometer sensors. The state machine designed by Chinrungrueng and Kaewkamnerd for a single lane is extended to $n$ motorway lanes with multiple lane changes. The proposed method has good performance in terms of the detection rate and the false detections, which are mainly due to the interference from a vehicle in an adjacent lane and lane changing. The state machine is evaluated on a real motorway and compared with industrial sensors.

Perioperative Transcutaneous Tibial Nerve Stimulation to Reduce Postoperative Ileus After Colorectal Resection: A Pilot Study.

Abstract: Background Postoperative ileus involves an inflammatory pathway characterized by an increase of inflammation mediators in the colon wall; this could probably be prevented by sacral nerve neuromodulation. The posterior tibial nerve can be stimulated electrically to mimic neuromodulation. Objective The aims of this study were to assess the efficacy of transcutaneous posterior tibial nerve stimulation in reducing the delay in GI motility recovery, to assess the safety of posterior tibial nerve stimulation in a perioperative setting, and to assess the efficacy of posterior tibial nerve stimulation in reducing the occurrence of postoperative ileus. Design This was a preliminary randomized controlled study. Settings This study was conducted in 1 academic hospital in France. Patients Forty patients undergoing an elective colectomy were included and randomly assigned into 2 groups, posterior tibial nerve stimulation or placebo, according to the side of colectomy and the surgical access size. Intervention Perioperative posterior tibial nerve stimulation or placebo was performed 3 times per day according to the randomly assigned group. Main outcome measures Delay in GI motility recovery (passage of stool and tolerance of solid food) was measured. Results Of the 40 patients included, 34 were included in the final analysis, in which 2 patients in the placebo group were allocated the incorrect device. The 6 other patients were secondarily excluded because of protocol deviation. In the intention-to-treat analysis, the mean delay in GI motility recovery was 3.6 and 3.11 days (in the placebo and tibial nerve stimulation groups; p = 0.60). Occurrence of postoperative ileus was not significantly higher in the placebo group (35.3% vs 17.6%; p = 0.42). In the per-protocol analysis, we observed the same trends except for the occurrence of postoperative ileus, which was significantly higher in the placebo group (p = 0.045). Tolerance to posterior tibial nerve stimulation was good, and all of the patients completed the protocol. Limitations The amplitude of stimulation is set according to patient sensation, so some patients could have been aware of their group. In addition there were some inherent limitations because of the preliminary nature of the study and several deviations from the protocol. Conclusions Posterior tibial nerve stimulation was safe in a perioperative setting and had a potential effect on GI motility recovery. The results of this study will be useful for sample size calculations in a larger prospective randomized trial. See Video Abstract at http://links.lww.com/DCR/A708.