Université Nantes Angers Le Mans

About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Finite element method. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.

Interest of a simple on-line screening registry for measuring ICU burden related to an influenza pandemic.

Abstract: The specific burden imposed on Intensive Care Units (ICUs) during the A/H1N1 influenza 2009 pandemic has been poorly explored. An on-line screening registry allowed a daily report of ICU beds occupancy rate by flu infected patients (Flu-OR) admitted in French ICUs. We conducted a prospective inception cohort study with results of an on-line screening registry designed for daily assessment of ICU burden. Among the 108 centers participating to the French H1N1 research network on mechanical ventilation (REVA) - French Society of Intensive Care (SRLF) registry, 69 ICUs belonging to seven large geographical areas voluntarily participated in a website screening-registry. The aim was to daily assess the ICU beds occupancy rate by influenza-infected and non-infected patients for at least three weeks. Three hundred ninety-one critically ill infected patients were enrolled in the cohort, representing a subset of 35% of the whole French 2009 pandemic cohort; 73% were mechanically ventilated, 13% required extra corporal membrane oxygenation (ECMO) and 22% died. The global Flu-OR in these ICUs was only 7.6%, but it exceeded a predefined 15% critical threshold in 32 ICUs for a total of 103 weeks. Flu-ORs were significantly higher in University than in non-University hospitals. The peak ICU burden was poorly predicted by observations obtained at the level of large geographical areas. The peak Flu-OR during the pandemic significantly exceeded a 15% critical threshold in almost half of the ICUs, with an uneven distribution with time, geographical areas and between University and non-University hospitals. An on-line assessment of Flu-OR via a simple dedicated registry may contribute to better match resources and needs.

Complete Chromosome Sequence of Carnobacterium maltaromaticum LMA 28

Abstract: Within the lactic acid bacterium genus Carnobacterium, Carnobacterium maltaromaticum is one of the most frequently isolated species from natural environments and food. It potentially plays a major role in food product biopreservation. We report here on the 3.649-Mb chromosome sequence of C. maltaromaticum LMA 28, which was isolated from ripened soft cheese.

The walking-induced transient hack concept is valid & relies on a transient early-exercise hypoxemia.

Abstract: Background Decreased arterial oxygen pressure obtained at peak exercise is strong evidence of walking-induced hypoxemia, assuming that the lower pressure occurs just before exercise is stopped. Using empirical predefined models and transcutaneous oximetry, we have shown that some patients reporting exercise intolerance show a minimal value at the onset of walking and a post-exercise overshoot. These changes are referred to as transcutaneous ?walking-induced transient hacks?. Methods In 245 patients, walking-induced transcutaneous oxygen pressure changes in the chest were analyzed using observer-independent clustering techniques. Clustering classes were compared to the profile types previously proposed with the cross-correlation technique. The classifications of patients according to both approaches were compared using kappa statistics. In 10 patients showing a hack on transcutaneous oximetry, we analyzed the results of direct iterative arterial sampling recorded during a new walking treadmill test. Results Clustering analysis resulted in 4 classes that closely fit the 4 most frequently proposed empirical models (cross-correlation coefficients: 0.93 to 0.97). The kappa between the two classifications was 0.865. In 10 patients showing transcutaneous hacks, the minimal direct arterial oxygen pressure value occurred at exercise onset, and these patients exhibited a recovery overshoot reaching a maximum at two minutes of recovery, confirming the walking-induced transient hypoxemia. Conclusions In patients reporting exercise intolerance, transcutaneous oximetry could help to detect walking-induced transient hypoxemia, while peak-exercise arterial oximetry might be normal. Citation: Bruneau A, Feuilloy M, Dussaussoy C, Gagnadoux F, Leftheriotis G, et al. (2013) The Walking-Induced Transient Hack Concept Is Valid & Relies on a Transient Early-Exercise Hypoxemia. PLoS ONE 8(5): e62651. doi:10.1371/journal.pone.0062651 Editor: Gisela Nogales-Gadea, University Hospital Vall d?Hebron, Spain Received: January 4, 2013; Accepted: March 25, 2013; Published: May 3, 2013 Copyright: © 2013 Bruneau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The project was funded and promoted by the University Hospital in Angers, and AB benefits the support of the ?Direction departementale de la cohesion sociale? and ?Comite departemental olympique et sportif?. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.

Towards Increased Visibility of Multimorbidity Research

Abstract: The number of people living with comorbidity, multimorbidity, or multiple chronic conditions, hereafter referred to as “multimorbidity” (see Box 1) [1,2], has become the norm rather than the exception in healthcare. In developed countries, approximately one in four adults have at least two chronic conditions [3,4], and over half of older adults have three or more [5]. Although the prevalence of multimorbidity increases with age, many studies have reported high rates of multimorbidity even among younger adults [6]. Multimorbidity negatively impacts patient outcomes, including physical and psychological functioning, quality of life, and life expectancy [7,8]. It also complicates treatment and increases healthcare utilization and costs [9–11]. Despite representing a large – and growing – proportion of adults seen in primary care today, there is a major gap in our understanding of how best to address, meet, and satisfy the complex care needs of patients with multimorbidity [11]. The traditional single-disease model of care does not work for them, and multimorbidity should definitively not be considered as the simple juxtaposition of independent conditions [12,13]. Fortunately though, interest in multimorbidity is growing worldwide, and has become a healthcare and research priority [14,15]. An international community interested in multimorbidity research has recently emerged and become organized through different activities, such as the creation of the Journal of Comorbidity , a weblog that hosts and supports the exchanges from the International Research Community on Multimorbidity [16], the organization of an international forum [17] at the North American Primary Care Research Group (NAPCRG) congress, and the publication of an “ABC of Multimorbidity” [1]. Journal of Comorbidity 2016;6(2):42–45