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Showing papers by "University of Bedfordshire published in 2018"


Journal ArticleDOI
TL;DR: In this paper, the authors used the literature to differentiate three types of environmental regulations (command-and-control regulations, market-based regulations and informal regulations) and further investigated the linear links between different types of ERs and EP, and the potential non-linear relationships.

169 citations


Journal ArticleDOI
TL;DR: The gamified course design advocated in this work may have significant implications for educators who wish to develop engaging technology-mediated learning environments that enhance students’ learning, or for a broader base of professionals who wishto engage a population of potential users.
Abstract: We evaluated the use of gamification to facilitate a student-centered learning environment within an undergraduate Year 2 Personal and Professional Development (PPD) course. In addition to face-to-face classroom practices, an information technology-based gamified system with a range of online learning activities was presented to students as support material. The implementation of the gamified course lasted two academic terms. The subsequent evaluation from a cohort of 136 students indicated that student performance was significantly higher among those who participated in the gamified system than in those who engaged with the nongamified, traditional delivery, while behavioral engagement in online learning activities was positively related to course performance, after controlling for gender, attendance, and Year 1 PPD performance. Two interesting phenomena appeared when we examined the influence of student background: female students participated significantly more in online learning activities than male students, and students with jobs engaged significantly more in online learning activities than students without jobs. The gamified course design advocated in this work may have significant implications for educators who wish to develop engaging technology-mediated learning environments that enhance students’ learning, or for a broader base of professionals who wish to engage a population of potential users, such as managers engaging employees or marketers engaging customers.

141 citations


Journal ArticleDOI
TL;DR: A rule-based adaptive LPA validation (LPAV) model, LPAV-IoT, is proposed for eliminating irregular uncertainties (IUs), estimating data reliability in IoT healthcare environments and a case study on a personalized healthcare platform myhealthavatar connecting three state-of-the-art wearable devices and mobile apps is carried out.
Abstract: Internet of Things (IoT) technology offers opportunities to monitor lifelogging data by a variety of assets, like wearable sensors, mobile apps, etc. But due to heterogeneity of connected devices and diverse human life patterns in an IoT environment, lifelogging personal data contains huge uncertainty and are hardly used for healthcare studies. Effective validation of lifelogging personal data for longitudinal health assessment is demanded. In this paper, lifelogging physical activity (LPA) is taken as a target to explore how to improve the validity of lifelogging data in an IoT enabled healthcare system. A rule-based adaptive LPA validation (LPAV) model, LPAV-IoT, is proposed for eliminating irregular uncertainties (IUs) and estimating data reliability in IoT healthcare environments. A methodology specifying four layers and three modules in LPAV-IoT is presented for analyzing key factors impacting validity of LPA. A series of validation rules are designed with uncertainty threshold parameters and reliability indicators and evaluated through experimental investigations. Following LPAV-IoT, a case study on a personalized healthcare platform myhealthavatar connecting three state-of-the-art wearable devices and mobile apps are carried out. The results reflect that the rules provided by LPAV-IoT enable efficiently filtering at least 75% of IU and adaptively indicating the reliability of LPA data on certain condition of IoT environments.

137 citations


Journal ArticleDOI
TL;DR: An introduction to Vehicle to Everything (V2X) communications and services alongside the corresponding service requirement is presented and security issues related to V2X communication in cellular network are presented leading towards possible research challenges.

129 citations


Journal ArticleDOI
TL;DR: The state-of-the-art in traditional PARM methodologies as used in the healthcare domain, including sensory, feature extraction and recognition techniques are summarized, and some key enabling techniques for tackling them are discussed.

123 citations


Journal ArticleDOI
TL;DR: Porosity was measured for 21 AA2319 wire and arc additive manufacture (WAAM) panels built using different wire batches, cold metal transfer (CMT) modes, wire feed speed (WFS) and travel speed (TS) as mentioned in this paper.

119 citations


Journal ArticleDOI
TL;DR: In this paper, a novel application of data envelopment analysis (DEA) is described to help extend a specific debate in the literature on Porter's hypothesis in environmental policy, which deals with the impact of flexibility of regulations on the relationship between innovation capabilities on financial performance in organisations.
Abstract: Operational research models have been employed to understand development issues associated with environmental sustainability. This article describes a novel application of data envelopment analysis (DEA) to help extend a specific debate in the literature on Porter's hypothesis in environmental policy. The debate deals with the impact of flexibility of regulations on the relationship between innovation capabilities on financial performance in organisations. Using the resource based view of a firm, we hypothesise that relationship between innovation capabilities and financial performance in firms depends on how flexible or inflexible environmental regulations are. We apply DEA to capture the flexibility of environmental regulations. Our results indicate that innovation capabilities significantly influence financial performance of firms if firms feel that the environmental regulations they face are flexible and offer more freedom in meeting the requirements of regulations. On the other hand, corporations that feel that they face more inflexible regulations are not so effective in improving their financial performance with their innovation capabilities.

110 citations


Journal ArticleDOI
TL;DR: A range of factors that facilitate and hinder the implementation and delivery of Social Prescribing services are identified to provide an insight for commissioners, managers, and providers to guide the implementationand delivery of future Social PresCribing services.
Abstract: Social Prescribing is a service in primary care that involves the referral of patients with non-clinical needs to local services and activities provided by the third sector (community, voluntary, and social enterprise sector). Social Prescribing aims to promote partnership working between the health and the social sector to address the wider determinants of health. To date, there is a weak evidence base for Social Prescribing services. The objective of the review was to identify factors that facilitate and hinder the implementation and delivery of SP services based in general practice involving a navigator. We searched eleven databases, the grey literature, and the reference lists of relevant studies to identify the barriers and facilitators to the implementation and delivery of Social Prescribing services in June and July 2016. Searches were limited to literature written in English. No date restrictions were applied. Findings were synthesised narratively, employing thematic analysis. The Mixed Methods Appraisal Tool Version 2011 was used to evaluate the methodological quality of included studies. Eight studies were included in the review. The synthesis identified a range of factors that facilitate and hinder the implementation and delivery of SP services. Facilitators and barriers were related to: the implementation approach, legal agreements, leadership, management and organisation, staff turnover, staff engagement, relationships and communication between partners and stakeholders, characteristics of general practices, and the local infrastructure. The quality of most included studies was poor and the review identified a lack of published literature on factors that facilitate and hinder the implementation and delivery of Social Prescribing services. The review identified a range of factors that facilitate and hinder the implementation and delivery of Social Prescribing services. Findings of this review provide an insight for commissioners, managers, and providers to guide the implementation and delivery of future Social Prescribing services. More high quality research and transparent reporting of findings is needed in this field.

108 citations


Posted ContentDOI
04 Jul 2018-bioRxiv
TL;DR: The results suggest that the Angiosperms353 probe set described here is effective for any group of flowering plants and would be useful for phylogenetic studies from the species level to higher-order lineages, including all angiosperm lineage.
Abstract: Sequencing of target-enriched libraries is an efficient and cost-effective method for obtaining DNA sequence data from hundreds of nuclear loci for phylogeny reconstruction. Much of the cost associated with developing targeted sequencing approaches is preliminary data needed for identifying orthologous loci for probe design. In plants, identifying orthologous loci has proven difficult due to a large number of whole-genome duplication events, especially in the angiosperms (flowering plants). We used multiple sequence alignments from over 600 angiosperms for 353 putatively single-copy protein-coding genes to design a set of targeted sequencing probes for phylogenetic studies of any angiosperm lineage. To maximize the phylogenetic potential of the probes while minimizing the cost of production, we introduce a k-medoids clustering approach to identify the minimum number of sequences necessary to represent each coding sequence in the final probe set. Using this method, five to 15 representative sequences were selected per orthologous locus, representing the sequence diversity of angiosperms more efficiently than if probes were designed using available sequenced genomes alone. To test our approximately 80,000 probes, we hybridized libraries from 42 species spanning all higher-order lineages of angiosperms, with a focus on taxa not present in the sequence alignments used to design the probes. Out of a possible 353 coding sequences, we recovered an average of 283 per species and at least 100 in all species. Differences among taxa in sequence recovery could not be explained by relatedness to the representative taxa selected for probe design, suggesting that there is no phylogenetic bias in the probe set. Our probe set, which targeted 260 kbp of coding sequence, achieved a median recovery of 137 kbp per taxon in coding regions, a maximum recovery of 250 kbp, and an additional median of 212 kbp per taxon in flanking non-coding regions across all species. These results suggest that the Angiosperms353 probe set described here is effective for any group of flowering plants and would be useful for phylogenetic studies from the species level to higher-order lineages, including all angiosperms.

100 citations


Journal ArticleDOI
TL;DR: Doxorubicin-induced mitophagy and mitochondrial damage in cardiomyocytes are mediated, at least in part, by dysregulation of the PINK1/parkin pathway.

99 citations


Journal ArticleDOI
TL;DR: Evidence from pooling four systematic reviews found that telehealth interventions produced a small but significant improvement in HbA1c levels compared with usual care, and the greatest effect was seen in telephone-delivered interventions, followed by Internet blood glucose monitoring system interventions and lastly interventions involving automatic transmission of SMBG using a mobile phone or a telehealth unit.
Abstract: There is a growing body of evidence to support the use of telehealth in monitoring HbA1c levels in people living with type 2 diabetes. However, the overall magnitude of effect is yet unclear due to variable results reported in existing systematic reviews. The objective of this study is to conduct a systematic review and meta-analysis of systematic reviews of randomised controlled trials to create an evidence-base for the effectiveness of telehealth interventions on glycemic control in adults with type 2 diabetes. Electronic databases including The Cochrane Library, MEDLINE, EMBASE, HMIC, and PsychINFO were searched to identify relevant systematic reviews published between 1990 and April 2016, supplemented by references search from the relevant reviews. Two independent reviewers selected and reviewed the eligible studies. Of the 3279 references retrieved, 4 systematic reviews reporting in total 29 unique studies relevant to our review were included. Both conventional pairwise meta-analyses and network meta-analyses were performed. Evidence from pooling four systematic reviews found that telehealth interventions produced a small but significant improvement in HbA1c levels compared with usual care (MD: -0.55, 95% CI: -0.73 to − 0.36). The greatest effect was seen in telephone-delivered interventions, followed by Internet blood glucose monitoring system interventions and lastly interventions involving automatic transmission of SMBG using a mobile phone or a telehealth unit. Current evidence suggests that telehealth is effective in controlling HbA1c levels in people living with type 2 diabetes. However there is need for better quality primary studies as well as systematic reviews of RCTs in order to confidently conclude on the impact of telehealth on glycemic control in type 2 diabetes.

Journal ArticleDOI
TL;DR: Results indicate that prolonged uninterrupted sitting in healthy desk workers reduces cerebral blood flow; however, this is offset when frequent short-duration walking breaks are incorporated into this sitting period.
Abstract: Prolonged uninterrupted sitting in healthy desk workers reduces cerebral blood flow. However, this reduction in cerebral blood flow is offset when frequent short-duration walking breaks are incorpo...

Journal ArticleDOI
TL;DR: The authors provide an overview of the historical influences that have shaped theoretical conceptualisations of interactional competence as it relates to spoken language use, and provide a discussion of the interaction between the two constructs.
Abstract: This article on interactional competence provides an overview of the historical influences that have shaped theoretical conceptualisations of this construct as it relates to spoken language use, le...

Journal ArticleDOI
TL;DR: An innovative scheduling framework able to select different scheduling rules according to instantaneous scheduler states in order to minimize the packet delays and packet drop rates for strict QoS requirements applications is proposed.
Abstract: Dominated by delay-sensitive and massive data applications, radio resource management in 5G access networks is expected to satisfy very stringent delay and packet loss requirements In this context, the packet scheduler plays a central role by allocating user data packets in the frequency domain at each predefined time interval Standard scheduling rules are known limited in satisfying higher quality of service (QoS) demands when facing unpredictable network conditions and dynamic traffic circumstances This paper proposes an innovative scheduling framework able to select different scheduling rules according to instantaneous scheduler states in order to minimize the packet delays and packet drop rates for strict QoS requirements applications To deal with real-time scheduling, the reinforcement learning (RL) principles are used to map the scheduling rules to each state and to learn when to apply each Additionally, neural networks are used as function approximation to cope with the RL complexity and very large representations of the scheduler state space Simulation results demonstrate that the proposed framework outperforms the conventional scheduling strategies in terms of delay and packet drop rate requirements

Journal ArticleDOI
TL;DR: Those working on the risk assessment of cosmetics have a unique opportunity to lead progress in the application of novel approaches, and cosmetic risk assessors are encouraged to consider these key principles when conducting or evaluating such assessments.

Proceedings ArticleDOI
28 Jun 2018
TL;DR: The paper discusses about the foreseen future of smart cities and what features characterise a smart city, as well as the benefits and challenges of smart city.
Abstract: Smart city provides solutions to our rapid urbanisation. There is a general and growing concern of the challenges, that cities will encounter based on the current growth pace. This paper elaborates on the benefits and challenges of smart cities. The paper also discusses about the foreseen future of smart cities and what features characterise a smart city.

Journal ArticleDOI
TL;DR: Neonatal care policy and planning for preterm babies should consider the implementation of interventions with most positive impact on outcomes, and interventions with both home and facility based components showed the most frequent positive impact across outcomes.
Abstract: Various intervention programs exist for parents of preterm babies and some systematic reviews (SRs) have synthesised the evidence of their effectiveness. These reviews are, however, limited to specific interventions, components, or outcomes, and a comprehensive evidence base is lacking. The aim of this meta-review was to appraise and meta-synthesise the evidence from existing SRs to provide a comprehensive evidence base on the effectiveness of interventions for parents of preterm infants on parental and infant outcomes. We conducted a comprehensive search of the following databases to identify relevant SRs: Cochrane library, Web of science, EMBASE, CINAHL, British Nursing Index, PsycINFO, Medline, ScienceDirect, Scopus, IBSS, DOAJ, ERIC, EPPI-Centre, PROSPERO, WHO Library. Additional searches were conducted using authors’ institutional libraries, Google Scholar, and the reference lists of identified reviews. Identified articles were screened in two stages against an inclusion criteria with titles and abstracts screened first followed by full-text screening. Selected SRs were appraised using the AMSTAR tool. Extracted data using a predesigned tool were synthesised narratively examining the direction of impact on outcomes. We found 11 SRs eligible for inclusion that synthesised a total of 343 quantitative primary studies. The average quality of the SRs was ‘medium’. Thirty four interventions were reported across the SRs with considerable heterogeneity in the structural framework and the targeted outcomes that included maternal-infant dyadic, maternal/parental, and infant outcomes. Among all interventions, Kangaroo Care (KC) showed the most frequent positive impact across outcomes (n = 19) followed by Mother Infant Transaction Program (MITP) (n = 14). Other interventions with most consistent positive impact on infant outcomes were Modified-Mother Infant Transaction Program (M-MITP) (n = 6), Infant Health and Development Program (IHDP) (n = 5) and Creating Opportunities for Parent Empowerment (COPE) (n = 5). Overall, interventions with both home and facility based components showed the most frequent positive impact across outcomes. Neonatal care policy and planning for preterm babies should consider the implementation of interventions with most positive impact on outcomes. The heterogeneity in interventions and outcomes calls for the development and implementation of an integrated program for parents of preterm infants with a clearly defined global set of parental and infant outcomes.

Journal ArticleDOI
TL;DR: The findings suggest that the orientation process contributed positively to students’ smooth induction and that resulted in having meaningful and engaging interactions, which eliminated the drawbacks of each educational approach and broadened the network of interactions.
Abstract: Our ongoing research is focusing on identifying and taxonomising the elements and the factors that affect learner engagement with virtual worlds when hybrid virtual learning models are used. Our main hypothesis links learner engagement with interactions, both in the virtual world and in the physical classroom. In order to examine this subject, there is an elaboration on and consideration of aspects such as the learners’ prior experiences in the use of virtual worlds, their preconceptions about using them as a learning tool and the impact that the instructional designers’ choices have on enhancing the opportunities for interactions. In this paper, we examine the impact that the orientation process has on university students who study computer science and have almost no experience in the use of virtual worlds. Our findings suggest that the orientation process contributed positively to students’ smooth induction and that resulted in having meaningful and engaging interactions. Furthermore, students’ simultaneous coexistence in both environments eliminated the drawbacks of each educational approach and broadened the network of interactions.

Journal ArticleDOI
TL;DR: This paper investigated how motivational processes influence students' proactive career behaviours using structural equation modelling and moderation/mediation analysis using a nested model approach, and found that students higher in mastery approach had greater perceived employability mediated by skill development and network building.
Abstract: The graduate labour market is highly competitive but little is known about why students vary in their development of employability This study contributes to the literature by applying goal-setting theory and the job demands–resources model to investigate how motivational processes influence students’ proactive career behaviours We tested four hypotheses using structural equation modelling and moderation/mediation analysis using a nested model approach; 432 undergraduates from 21 UK universities participated in this cross-sectional study The results showed that students higher in mastery approach had greater perceived employability mediated by two proactive career behaviours (skill development and network building) Students’ career goal commitment was associated with all four proactive career behaviours (career planning, skill development, career consultation and network building) Students’ academic and employment workloads did not negatively impact their proactive career behaviours Universit

Journal ArticleDOI
TL;DR: In this paper, the authors argue for the existence of a curvilinear relationship between environmental performance (EP) and firm performance (FP) and empirically test the same using survey data on UK manufacturing firms.
Abstract: The nature of the relationship between environmental performance (EP) and firm performance (FP) of corporations is a long standing and contentious issue in the literature. This study is intended to advance this debate by arguing for the existence of curvilinear relationship and empirically testing the same using survey data on UK manufacturing firms. FP is captured in terms of growth in sales and market share. Our results show evidence for a quadratic relationship—as firms improve their EP, they seem to achieve much higher levels of FP. These results are consistent with the resource-based view of a firm; as firms engage in EP activities, they are able to gain inimitable knowledge that helps in further learning to further improve performance. Based on our results, we suggest that new studies focus on strategies to extend the period of increasing returns and maximizing the benefits of the positive association between EP and FP.

Journal ArticleDOI
TL;DR: This review considers the techniques that have, over the years, been employed to modify the colour of the authors' food, and the interactions of these techniques with issues of safety and nutrition.
Abstract: Whether we are purchasing fresh vegetables from a market stall, ready meals from the supermarket, eating at home or in a five‐star restaurant, we use colour to tell us what to expect in terms of taste, nutrition and safety. This review considers the techniques that have, over the years, been employed to modify the colour of our food, and the interactions of these techniques with issues of safety and nutrition. The demand for brightly coloured food resulted in the incorporation of some questionable inorganic and organic chemistry being used in food products. A limited number of synthetic dyes are still used in food today, but health concerns and the consumer‐driven demand for natural colorants has brought about a change in the way food is coloured. The proliferation of products with labels that state they contain “No artificial colours” on supermarket shelves suggests that the future of azo dyes and their various derivatives is strictly limited. Nature produces an abundance of colours and many of these are extracted and used as natural food colorants; however, they are subject to application limitations and stability problems. Significant research by academia and industry into methods to stabilise and expand the application possibilities for the various approved natural food colorants is ongoing, but most developments that food colour manufacturers proclaim are enhanced vehicles for delivering established natural pigments into food products.

Journal ArticleDOI
TL;DR: Investigation into the design and evaluation of wandering scenarios with patients suffering from dementia using an S-band sensing technique and results show that the proposed technique carries high classification accuracy up to 90% and has good potential for healthcare applications.
Abstract: Increasing prevalence of dementia has posed several challenges for care-givers. Patients suffering from dementia often display wandering behavior due to boredom or memory loss. It is considered to be one of the challenging conditions to manage and understand. Traits of dementia patients can compromise their safety causing serious injuries. This paper presents investigation into the design and evaluation of wandering scenarios with patients suffering from dementia using an S-band sensing technique. This frequency band is the wireless channel commonly used to monitor and characterize different scenarios including random, lapping, and pacing movements in an indoor environment. Wandering patterns are characterized depending on the received amplitude and phase information of that measures the disturbance caused in the ideal radio signal. A secondary analysis using support vector machine is used to classify the three patterns. The results show that the proposed technique carries high classification accuracy up to 90% and has good potential for healthcare applications.


Journal ArticleDOI
TL;DR: Active workstations do not appear to decrease workplace performance and sit-stand desks had no detrimental effect on performance, however, some studies with treadmill and cycling workst stations identified potential decreases in performance.
Abstract: Active workstations have been recommended for reducing sedentary behavior in the workplace. It is important to understand if the use of these workstations has an impact on worker productivity. The aim of this systematic review was to examine the effect of active workstations on workplace productivity and performance. A total of 3303 articles were initially identified by a systematic search and seven articles met eligibility criteria for inclusion. A quality appraisal was conducted to assess risk of bias, confounding, internal and external validity, and reporting. Most of the studies reported cognitive performance as opposed to productivity. Five studies assessed cognitive performance during use of an active workstation, usually in a single session. Sit-stand desks had no detrimental effect on performance, however, some studies with treadmill and cycling workstations identified potential decreases in performance. Many of the studies lacked the power required to achieve statistical significance. Three studies assessed workplace productivity after prolonged use of an active workstation for between 12 and 52 weeks. These studies reported no significant effect on productivity. Active workstations do not appear to decrease workplace performance.

Journal ArticleDOI
TL;DR: The ability to interact with others has gained recognition as part of the L2 speaking construct in the assessment literature and in high and low-stakes speaking assessments as mentioned in this paper, and it has been recognized as one of the strengths of L2.
Abstract: The ability to interact with others has gained recognition as part of the L2 speaking construct in the assessment literature and in high- and low-stakes speaking assessments. This paper first prese...

Journal ArticleDOI
05 Apr 2018-Viruses
TL;DR: It is clear that bacteriophages are not a “magic bullet”, but with careful and appropriate selection of a limited set of initial targets, it should be possible to obtain proof of concept for the many elements required for the success of phage therapy.
Abstract: One of the main issues with phage therapy from its earliest days has been the selection of appropriate disease targets. In early work, when the nature of bacteriophages was unknown, many inappropriate targets were selected, including some now known to have no bacterial involvement whatsoever. More recently, with greatly increased understanding of the highly specific nature of bacteriophages and of their mechanisms of action, it has been possible to select indications with an increased chance of a successful therapeutic outcome. The factors to be considered include the characteristics of the infection to be treated, the characteristics of the bacteria involved, and the characteristics of the bacteriophages themselves. At a later stage all of this information then informs trial design and regulatory considerations. Where the work is undertaken towards the development of a commercial product it is also necessary to consider the planned market, protection of intellectual property, and the sourcing of funding to support the work. It is clear that bacteriophages are not a “magic bullet”. However, with careful and appropriate selection of a limited set of initial targets, it should be possible to obtain proof of concept for the many elements required for the success of phage therapy. In time, success with these initial targets could then support more widespread use.

Journal ArticleDOI
TL;DR: In this paper, the authors examined the relationship between ethnic identity, dual ethnocentrism, and purchase intentions among ethnic consumers, and found that indeed ethnocentric feelings and their effects differ depending on the country of reference.

Journal ArticleDOI
TL;DR: Research and anecdotal evidence suggest that researchers do not commonly provide feedback to PPI contributors thus preventing them from knowing whether, how or where their contributions were useful to researchers and research overall.
Abstract: Background: Reciprocal relationships between researchers and patient and public involvement (PPI) contributors can enable successful PPI in research. However, research and anecdotal evidence suggest that researchers do not commonly provide feedback to PPI contributors thus preventing them from knowing whether, how or where their contributions were useful to researchers and research overall. Aims: The aim of this study was to explore the variation, types, importance of, and satisfaction with feedback given by researchers to PPI contributors in six PPI groups in England, and identify the barriers to the process of feedback. Methods: An explanatory mixed methods sequential study design with a questionnaire survey followed by semi‐structured interviews with researchers and PPI contributors in six PPI groups. PPI contributors were involved in all stages of the research process. Results: Researchers do not routinely give feedback to PPI contributors. Feedback was found to have different meanings: an acknowledgement, impact and study success and progress. PPI contributors who receive feedback are motivated for further involvement; it supports their learning and development and prompts researchers to reflect on PPI impact. The importance of the role of a PPI lead or coordinator to facilitate the process of providing feedback was also highlighted. Conclusion: This study found no generic way to give feedback indicating that mutual feedback expectations should be discussed at the outset. PPI feedback needs to become integral to the research process with appropriate time and resources allocated. PPI feedback can be seen as a key indicator of mature, embedded PPI in research.

Journal ArticleDOI
06 Mar 2018-Biology
TL;DR: This review will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GMmicroalgae in Europe.
Abstract: It is abundantly clear that the development of gene editing technologies, represents a potentially powerful force for good with regard to human and animal health and addressing the challenges we continue to face in a growing global population. This now includes the development of approaches to modify microalgal strains for potential improvements in productivity, robustness, harvestability, processability, nutritional composition, and application. The rapid emergence and ongoing developments in this area demand a timely review and revision of the current definitions and regulations around genetically modified organisms (GMOs), particularly within Europe. Current practices within the EU provide exemptions from the GMO directives for organisms, including crop plants and micro-organisms that are produced through chemical or UV/radiation mutagenesis. However, organisms generated through gene editing, including microalgae, where only genetic changes in native genes are made, remain currently under the GMO umbrella; they are, as such, excluded from practical and commercial opportunities in the EU. In this review, we will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GM microalgae in Europe.

Journal ArticleDOI
TL;DR: Physical literacy is an end in itself rather than predominantly a means to other ends as mentioned in this paper, and the value of physical literacy can be found in philosophy, neuroscience, social justice, the nature of human development, psychology, and sociocultural studies.
Abstract: This article considers the value of physical literacy Unequivocal support for aspects of the concept can be found in philosophy, neuroscience, social justice, the nature of human development, psychology, and sociocultural studies These areas of support will be outlined and then related to the practical value of physical literacy in the school context This article will close with a discussion centered on claims that physical literacy is an end in itself rather than predominantly a means to other ends It is the aim of this article to communicate the unique value of fostering physical literacy within the school context, including the support and relationship to other interrelated disciplines