University of Maribor

About: University of Maribor is a education organization based out in Maribor, Slovenia. It is known for research contribution in the topics: Population & KEKB. The organization has 3987 authors who have published 13077 publications receiving 258339 citations. The organization is also known as: Univerza v Mariboru.

Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease.

Abstract: Increasing evidence suggests that not only genetics, but also environmental factors like gut microbiota dysbiosis play an important role in the pathogenesis of celiac disease (CD). The aim of our study was to investigate the effect of two probiotic strains Bifidobacterium breve BR03 and B. breve B632 on serum production of anti-inflammatory cytokine interleukin 10 (IL-10) and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) in children with CD. The study was a double-blinded, placebo-controlled trial that included 49 children with CD on gluten-free diet (GFD) randomized into two groups and 18 healthy children in the control group. The first group (24 children with CD) daily received B. breve BR03 and B632 (2 × 109 colony-forming units) and the second group (25 children with CD) received placebo for 3 months. TNF-α levels were significantly decreased in the first group after receiving B. breve for 3 months. On follow-up, 3 months after receiving probiotics, TNF-α levels increased again. Children with CD who were on GFD for less than 1 year showed similar baseline TNF-α levels as children who were on GFD for more than 1 year. IL-10 levels were in all groups of patients below detection level. Probiotic intervention with B. breve strains has shown a positive effect on decreasing the production of pro-inflammatory cytokine TNF-α in children with CD on GFD.

How cognitive, metacognitive, motivational and emotional self‐regulation influence school performance in adolescence and early adulthood

Abstract: This contribution aims to examine how different areas of self‐regulation are related to academic achievement in adolescents and young adults. The study involved participants, drawn from following age groups: 14–15, 17–18 and 22–23. In order to get information about cognitive, metacognitive, motivational and emotional aspects of self‐regulation, self‐report questionnaires were used. Differences between age‐groups revealed following tendency: there has been a decrease in all fields of self‐regulation from age of 14 (end of primary school) to the age of about 18 years (end of secondary school), and then results slowly improved to the age of about 22 years (students of undergraduate studies). The results obtained are mirroring perceived competence of self‐regulation and differ from the results concerning metacognitive accuracy. Metacognitive self‐regulation persists as an important predictor of school achievement at all developmental levels, and the motivational self‐regulation has significant impact on perfo...

Phase diagrams for three-strategy evolutionary prisoner’s dilemma games on regular graphs

Abstract: Evolutionary prisoner's dilemma games are studied with players located on square lattice and random regular graph defining four neighbors for each one. The players follow one of the three strategies: tit-for-tat, unconditional cooperation, and defection. The simplified payoff matrix is characterized by two parameters: the temptation b to choose defection and the cost c of inspection reducing the income of tit-for-tat. The strategy imitation from one of the neighbors is controlled by pairwise comparison at a fixed level of noise. Using Monte Carlo simulations and the extended versions of pair approximation we have evaluated the b-c phase diagrams indicating a rich plethora of phase transitions between stationary coexistence, absorbing, and oscillatory states, including continuous and discontinuous phase transitions. By reasonable costs the tit-for-tat strategy prevents extinction of cooperators across the whole span of b determining the prisoner's dilemma game, irrespective of the connectivity structure. We also demonstrate that the system can exhibit a repetitive succession of oscillatory and stationary states upon changing a single payoff value, which highlights the remarkable sensitivity of cyclical interactions on the parameters that define the strength of dominance.

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization

Abstract: OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to functional blood vessel formation after transplantation. We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization rate, vascular density, and endocrine graft function after transplantation of freshly isolated and cultured islets. RESEARCH DESIGN AND METHODS Freshly isolated and cultured islets were transplanted under the kidney capsule and into the anterior chamber of the eye. Intravital laser-scanning microscopy was used to monitor the revascularization process and DIECs in intact grafts. The grafts’ metabolic function was examined by reversal of diabetes, and the ultrastructural morphology by transmission electron microscopy. RESULTS DIECs significantly contributed to the vasculature of fresh islet grafts, assessed up to 5 months after transplantation, but were hardly detected in cultured islet grafts. Early participation of DIECs in the revascularization process correlated with a higher revascularization rate of freshly isolated islets compared with cultured islets. However, after complete revascularization, the vascular density was similar in the two groups, and host ECs gained morphological features resembling the endogenous islet vasculature. Surprisingly, grafts originating from cultured islets reversed diabetes more rapidly than those originating from fresh islets. CONCLUSIONS In summary, DIECs contributed to the revascularization of fresh, but not cultured, islets by participating in early processes of vessel formation and persisting in the vasculature over long periods of time. However, the DIECs did not increase the vascular density or improve the endocrine function of the grafts.

Recent progressive use of atomic force microscopy in biomedical applications

Abstract: In recent years, a great deal of interest has been focused on the development of novel atomic force microscopy (AFM)-based methods. From first being an unstable method, AFM has emerged as the perfect tool for the study of phenomena at the nanoscale, which includes quantitative single molecule studies. Numerous novel AFM methods play a crucial role in the invention of novel drugs, their delivery systems, based on either polymers or inorganic/metallic matrices, and in the examination of disease-related tissue changes. Such contemporary progressive studies are a perfect example of interdisciplinary research, which results in exemplary findings and discoveries. This review focuses especially on the literature published in the last decade; however the most important earlier discoveries are also included.