University of Zurich

About: University of Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Medicine. The organization has 50842 authors who have published 124042 publications receiving 5304521 citations. The organization is also known as: UZH & Uni Zurich.

West European Politics in the Age of Globalization

Abstract: Over the past three decades the effects of globalization and denationalization have created a division between ‘winners’ and ‘losers’ in Western Europe. This study examines the transformation of party political systems in six countries (Austria, France, Germany, the Netherlands, Switzerland and the UK) using opinion surveys, as well as newly collected data on election campaigns. The authors argue that, as a result of structural transformations and the strategic repositioning of political parties, Europe has observed the emergence of a tripolar configuration of political power, comprising the left, the moderate right, and the new populist right. They suggest that, through an emphasis on cultural issues such as mass immigration and resistance to European integration, the traditional focus of political debate - the economy - has been downplayed or reinterpreted in terms of this new political cleavage. This new analysis of Western European politics will interest all students of European politics and political sociology.

S100 proteins: structure, functions and pathology.

Abstract: S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. Twenty members have been identified so far, and altogether, S100 proteins represent the largest subgroup in the EF-hand Ca2+ -binding protein family. A unique feature of these proteins is that individual members are localized in specific cellular compartments from which some are able to relocate upon Ca2+ activation, transducing the Ca2+ signal in a temporal and spacial manner by interacting with different targets specific for each S100 protein. Some members are even secreted from cells exerting extracellular, cytokine-like activities partially via the surface receptor RAGE (receptor for advanced glycation endproducts) with paracrine effects e.g. on neurons, promoting their survival during development or after injury. Another important aspect is that 14 bona fide S100 genes are found in a gene cluster on human chromosome 1q21 where a number of chromosomal abnormalities occur. This results in a deregulated expression of some S100 genes associated with neoplasias. Recently, S100 proteins have received increasing attention due to their close association with several human diseases including cardiomyopathy, neurodegenerative disorders and cancer. They have also been proven to be valuable in the diagnostic of these diseases, as predictive markers of improving clinical management, outcome and survival of patients and are considered having a potential as drug targets to improve therapies.

A New Benzodiazepine Pharmacology

Abstract: Classical benzodiazepine drugs are in wide clinical use as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. They act by enhancing the γ-aminobutyric acid A (GABA A ) receptor function in the central nervous system. The pharmacological relevance of the multitude of structurally diverse GABA A receptor subtypes has only recently been identified. Based on an in vivo point mutation strategy, α 1 -GABA A receptors were found to mediate sedation, anterograde amnesia, and part of the seizure protection, whereas α 2 -GABA A receptors, but not α 3 -receptors, mediate anxiolysis. Rational drug targeting to specific receptor subtypes has now become possible. Only restricted neuronal networks will be modulated by the new subtype-selective drugs. Promising new anxiolytics have already been developed. A new pharmacology of the benzodiazepine site is on the horizon.