Showing papers in "Molecular Brain Research in 1989"

TL;DR: This paper found an absence of luteinizing hormone-releasing hormone (LHRH)-expressing cells in the brain despite dense clusters of LHRH cells and fibers in the nose.

TL;DR: In this paper, the authors show that peripheral inflammation produces a rapid elevation in preprodynorphin mRNA in neurons of the dorsal spinal cord and an even more rapid increase in c-fos proto-oncogene mRNA (within 30 min).

TL;DR: In this paper, the authors showed that HSP72 immunocytochemistry may be used as a marker of cellular injury in the mammalian brain and used it to diagnose brain infarction.

TL;DR: Findings indicate that perinatal gonadal steroids influence the number of cells within the AVPv that express TH in detectable amounts by determining thenumber of cells that are capable of producing sufficient quantities of TH message, as opposed to sex-specific alterations in the post-translational mechanisms.

TL;DR: Results demonstrated an activation of VIP biosynthesis in the DRG neurons due to axotomy of the peripheral branch, which was opposite to the reaction of PPT mRNA to the same treatment.

TL;DR: The short latency of the estrogen-induced elevation and the rapid rate of decay following estrogen removal indicate that PE gene expression is highly sensitive to fluctuating estrogen levels.

TL;DR: In this article, the alpha 2-adrenoreceptor antagonist, yohimbine, was found to induce a transient increase in c-fos mRNA levels in rat brain, which was larger in magnitude (averaging 9.6-fold) and longer in duration than injection of the drug vehicle alone.

TL;DR: In this paper, a mechanism whereby antidepressants, by restoring the sensitivity of the limbic-hypothalamic system to glucocorticoid feedback inhibition, reverse the hyperactivity of the brain-pituitary-adrenal axis was proposed.

TL;DR: Nerve growth factor (NGF) receptor mRNA was found to be widely distributed throughout the human central nervous system, with the highest levels in the basal forebrain; this suggests that NGF may function as a retrograde trophic messenger for basal fore brain magnocellular cholinergic nerve cells.

TL;DR: The utility of grafting genetically modified cells to the mammalian brain was examined using the E. coli beta-galactosidase gene (lacZ) as a reporter gene in retroviral infection as mentioned in this paper.

TL;DR: Results suggest that tubulin mRNA levels are increased mainly through selective stabilization by insulin and IGFs, and stabilization of tubulin mRNAs is suggested to be a common event in the pathway leading to neurite elongation directed by neuritogenic polypeptides.

TL;DR: The view that estradiol stimulates the levels of both proGnRH-GAP mRNA and its primary translation product in the POA-AH region of the OVX rat is supported.

TL;DR: The inhibition of polysomal mRNA translation is a mechanism by which gene expression is impaired in pathologically involved brain regions of individuals afflicted by Alzheimer's disease.

TL;DR: In this paper, the authors characterized stages in the posttranslational processing of the three neurofilament subunits, High (NF-H), Middle and Low, in retinal ganglion cells in vivo during the interval between synthesis in cell bodies within the retina and appearance of these polypeptides in axons at the level of the optic nerve (optic axons).

TL;DR: Results at the level of the spinal cord showed that differential responses of PPE neurons related to the pain sensation occurred trans-synaptically after nociceptive stimulation applied to the periphery.

TL;DR: Various combinations of synthetic acetylcholine receptor (AChR) subunit mRNAs were injected into Xenopus oocytes, and assembly of incomplete AChRs and their insertion into the plasma membrane was studied, suggesting that N-glycosylation of AChR subunits is not a prerequisite for receptor assembly, but is required for their efficient insertion intoThe plasma membrane.

TL;DR: Results suggest that the nigral dopaminergic neurons tonically inhibit PPE gene expression in the striatum of monkeys depleted of dopamine by pretreatment with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

TL;DR: The tissue distribution and the ontogeny of GS mRNA expression in the rat brain from embryonic day 14 (E14) to adulthood, and localization of GS to astrocytes in the brain was confirmed using both immunocytochemistry and in situ hybridization.

TL;DR: A caudal-rostral gradient in expression of the beta-S-100 gene during rat brain development, as well as pronounced regional differences which may reflect the differentiation of subpopulations of astrocytes are demonstrated.

TL;DR: It is concluded that activation of PKC down-regulates the responses to 5-HT, ACh and GABA, and has a dual effect on response to kainate.

TL;DR: A cross-linking/immunoprecipitation assay demonstrated normal, membrane-bound NGF receptors within extracts of dorsal superior colliculus, ventromedial hypothalamic, and overlying meningial tissues, proving that the staining observed in these areas was not a non-specific artifact associated with the immunohistochemistry.

TL;DR: It is proposed that chronic lesions have long-term effects on gene expression because of damage sustained during compensatory hyperactivity after the lesion, or because of decreased trophic support from other neurons.

TL;DR: Surprisingly, FLI decreased in contralateral sensory cortex, mainly in layers 2, 3 and 6, up to several days after the lesion, which may be due to decreased sensory neuronal activity, and/or to reducing the trophic influence of thalamic inputs on cortical neurons.

TL;DR: It is demonstrated that P increases LHRH mRNA level in the hypothalamus of OVX + E-primed immature rats, and the mechanism underlying ovarian steroid action on gene expression of hypothalamic luteinizing hormone releasing hormone (LHRH) is investigated.

TL;DR: In this paper, an expression library representing mouse brain mRNA was screened using antisera that recognizes the 11 kDa DBI protein and a cDNA clone was isolated and sequenced.

TL;DR: The α1-transcript is considerably enriched in the inferior colliculus, olfactory bulb and substantia nigra, and appears to be correlated with benzodiazepine type I receptor localization.

TL;DR: Results indicate that c-ras p21s are mainly localized in the synaptic plasma membranes and microsomes and suggest that they may participate in some specific neuronal functions at these sites.

TL;DR: In situ hybridization with an oligomer for the L HRH coding region is used to detect LHRH gene expressing cells and to study LHRh message levels in estrogen treated compared to control ovariectomized rats.

TL;DR: The data suggest that somatostatin may be one of the factors involved in the chain of events leading to kindled seizures.

TL;DR: Neurons expressing glutamic acid decarboxylase (GAD) mRNA were localized by in situ hybridization in normal and monocularly deprived cat visual cortex by using single-stranded RNA probes transcribed from cDNAs cloned in vectors with the T3 and T7 RNA polymerase promoters to determine whether decreased retinal activity affected the levels of GAD mRNA.