Showing papers in "Parkinsonism & Related Disorders in 2020"

TL;DR: Evidence from studies on specific genes and proteins, their roles in the ALP, and the potential mechanisms underlying the involvement of these genes in PD are focused on.

TL;DR: The frailty caused by advanced PD poses an increased risk of mortality during COVID-19, a multi-centre cohort of PD patients followed in Italy, Iran, Spain, and the UK.

TL;DR: Current pharmacologic and non-pharmacologic methods of treatment, prior and ongoing clinical trials in PSP, and in vivo biomarkers including MRI, PET, and CSF biomarkers are reviewed.

TL;DR: Differential microbial compositions in HS and HP samples demonstrate that the gut microbiota are also affected by family environment, and disease-associated metagenomics studies should consider the family environmental factor.

TL;DR: LEAPD is described, an efficient algorithm that is suitable for real time application and captures spectral EEG features using few parameters and reliably differentiates PD patients from demographically-matched controls.

TL;DR: The main reasons for hospitalisation among people with PD are infections, worsening motor features, falls/fractures, cardiovascular co-morbidities, neuropsychiatric and gastrointestinal complications.

TL;DR: The COVID-19 pandemic had a clear impact on exercise and subjective symptoms in PD patients, with reduced exercise being related to a subjective increase in both motor and non-motor symptoms of PD.

TL;DR: As an adjunct to l-DOPA, safinamide safely increased ON-time and improved PD symptoms/signs in PD patients with wearing-off.

TL;DR: The presence of GI symptoms may serve as an early marker of cognitive impairment in PD, and future studies should examine specific mechanisms underlying the relationship between gut-dysbiosis and cognitive impairment.

TL;DR: Serum NfL levels reflect cortical neurodegeneration from the very early stages of PD, and its brain structural correlates and its lack of relationship with dopaminergic depletion or amyloidosis suggests that N fL could track the underlying pathological process leading to PD dementia.

TL;DR: Supine hypertension in patients with nOH was associated with an increased risk for target organ damage, cardiovascular events, and premature death and was independently associated with earlier incidence of cardiovascular events and death.

TL;DR: In this article, the authors studied non-motor symptoms (NMS), which often precede motor impairments, add complexity to the burden of Parkinson's disease and its management.

TL;DR: Therapeutic strategies devised to minimize the potential that gastric complications will impair oral levodopa absorption and efficacy in PD patients include treatments that circumvent the GI tract, such as apomorphine injection, levodOPA intestinal gel delivery, levdopa inhalation powder, and deep brain stimulation.

TL;DR: A large number of Parkinson's disease patients in this study had difficulty in availing formal neurology consultations and/or medicines during home confinement, leading to a decline in quality of life.

TL;DR: Assessment of patients with functional motor symptoms found the use of two innovative approaches for FMS (physiotherapy and telemedicine), combined together, might have a valuable role in the treatment of this neuropsychiatric condition.

TL;DR: The approach suggests WES as an efficient tool to improve the diagnostic yield after gene panel sequencing in dystonia and a potential genetic overlap between neurodevelopmental diseases and dySTONia is suggested.

TL;DR: Cepstral analysis and machine-learning algorithms are new tools that offer meaningful support to clinicians in the diagnosis and treatment of adductor-type spasmodic dysphonia.

TL;DR: After review of the current literature for antipsychotic therapy in both PDD and DLB, a logical framework for addressing psychotic symptoms in each condition is provided.

TL;DR: Telehealth keeps patients with parkinsonism safe from traveling to in-person care site during the COVID-19 mitigation phase, and this two-step model integrates a telenursing forward triage followed by video-consultations by experienced neurologists.

TL;DR: Investigation of non-motor symptoms, such as cognitive impairment, require careful consideration of the nature of cognitive deficits to characterize regional and network specific impairment, and iron, neuromelanin, and diffusion sensitive measures demonstrate high specificity and sensitivity in distinguishing Parkinson's disease relative to controls.

TL;DR: In this article, the A2A binding sites are selectively populated with a subtype of adenosine binding sites (A2A receptors) that offer a target for improving PD symptomatology.

TL;DR: A pipeline for a machine learning-based analytical method, allowing for detailed image-based cell profiling and toxicity prediction in brain organoids treated with the neurotoxic compound 6-hydroxydopamine, is described.

TL;DR: Data support long-term efficacy and safety of repeated incobotulinumtoxinA treatment for sialorrhea, with no additional safety concerns reported over 64 weeks.

TL;DR: It is suggested that cerebellar modulation may improve ataxic symptom and provide reassurance about safety for clinical practice and the protocol was safe and well-tolerated.

TL;DR: The observed reduction of M1S1 11C-MeNER binding in iRBD may represent noradrenergic terminal degeneration or physiological down-regulation of NARTs in this prodromal phenotype of PD.

TL;DR: Improvements in motor scores, OFF time, and patient-reported outcomes support clinical efficacy for up to 12 months of CVT-301.

TL;DR: In those with OSA, CPAP use was associated with stabilization of motor function (mUPDRS and TUG) over 12 months, and these observations support further research to clarify the role of OSA in PD pathophysiology and motor dysfunction.

TL;DR: GBA mutations are associated with early cognitive decline following STN-DBS and Neuropsychological assessment and discussions on the benefit/risk ratio of DBS are particularly important for this population.