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153Sm3+ and 111In3+ DTPA derivatives with high hepatic specificity: in vivo and in vitro studies

M. I. M. Prata, +4 more
- 25 Jul 2002 - 
- Vol. 91, Iss: 1, pp 312-319
TLDR
Two DTPA derivatives, a mono-amide derivative containing an iodinated synthon, DTPA-IOPsp and the ligand DTPA(BOM) 3, were studied as potential hepatospecific gamma scintigraphic agents, showing that the main excretory pathway for all the chelates studied is the hepatobiliary system.
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This article is published in Journal of Inorganic Biochemistry.The article was published on 2002-07-25 and is currently open access. It has received 10 citations till now.

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Journal ArticleDOI

The thermodynamics of the formation of Sm(III) mixed-ligand complexes carrying α-amino acids

Julia Torres, +5 more
- 20 Nov 2003 - 
TL;DR: In this article, a tricapped trigonal prism was constructed around a nine coordinate Sm atom, surrounded by two N atoms and six O atoms from two nta ligands and one O from a water molecule.
Journal ArticleDOI

Eu(III) and Tb(III) luminescent lanthanide systems derived from DTPA-bisamide and DTTA-based ligands incorporating bipyridine antenna

J.-M. Couchet, +7 more
- 01 Dec 2011 - 
TL;DR: The role played by non-radiative paths (vibrational energy transfer involving coordinated water molecules, involvement of ligand-to-metal charge-transfer excited states, or metal→ligand back-transfer) was investigated in this paper.
Journal ArticleDOI

Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver

Julia Greiser, +2 more
- 16 Sep 2019 - 
TL;DR: This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver and provides an overview on approved pharmaceuticals like Gd-based CA and 99mTc-based radiometal complexes, and also on novel agents such as 68Ga-based PET tracers.
Journal ArticleDOI

Biological studies of samarium-153 bleomycin complex in human breast cancer murine xenografts for therapeutic applications

Ali Bahrami-Samani, +3 more
- 01 Jan 2010 - 
TL;DR: The initial experiments demonstrate significant accumulation of 153Sm-BLM in tumor tissues, and demonstrates superior tumor accumulation properties in contrast with the other radiolabeled bleomycins with tumor: blood ratios at 4, 24 and 48 h, respectively, and tumor: muscle ratios while administered intravenously.

Evaluation of Hepatotoxicity of Lanthanide Complexes of Fish Catla catla

Meshram Nitin P, +1 more
TL;DR: Chelating complexes of various lanthanide series interact with biological tissue matter differently and may show highly specific responses with respect to tissue atrophy, tissue modification, antihaemolytic and even prevention of intravenous blood clotting.
References
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Book

Table of Isotopes

Richard B. Firestone, +1 more
TL;DR: In this paper, a 2-volume work contains nuclear structure and decay data for over 3,100 isotopes and isomers and extensive appendices have been entirely rewritten, expediting retrieval and use of nuclear information for many areas of research.
Journal ArticleDOI

Ligand design for selective complexation of metal ions in aqueous solution

Robert D. Hancock, +1 more
- 01 Dec 1989 - 
Book

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Andre E. Merbach, +1 more
TL;DR: This paper presents physical principles of Medical Imaging by Nuclear Magnetic Resonance and EPR Methods in Contrast Agent Research: Examples from GdA+ Chelates, a comparison of Frequency and Frequency Aspects of Lanthanide(III) Complexes.
Journal ArticleDOI

MS-325: albumin-targeted contrast agent for MR angiography.

Randall B. Lauffer, +7 more
- 01 May 1998 - 
TL;DR: As the first gadolinium-based blood pool agent in human trials, MS-325 has the potential to enhance both dynamic and steady-state MR angiograms and provides vascular signal enhancement superior to that provided with other agents.
Journal Article

Mechanisms of bile formation, hepatic uptake, and biliary excretion.

Curtis D. Klaassen, +1 more
- 01 Mar 1984 - 
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13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation

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Frequently Asked Questions (1)
Q1. What contributions have the authors mentioned in the paper "Sm and in dtpa derivatives with high hepatic specificity: in vivo and in vitro studies" ?

Two DTPA derivatives, a mono-amide derivative containing an iodinated synthon, DTPA-IOPsp ( L ) and the ligand DTPA ( BOM ) 1 3 153 31 111 31 ( BOM5benzyloxymethyl ) ( L ), radiolabelled with Sm and In, were studied as potential hepatospecific gamma scintigraphic 2 agents. In vivo studies with Wistar rats show that the main excretory pathway for all the chelates studied is the hepatobiliary system. The La 31 1 and In chelates of L and L show some structural and dynamic differences in aqueous solution, as studied by H NMR spectroscopy.