Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Spherical Nucleic Acids as Precision Therapeutics for the Treatment of Cancer—From Bench to Bedside
TL;DR: This review highlights seminal studies that identified SNAs as a powerful platform for gene regulation, the activation of innate immunity, and the development of next-generation cancer vaccines, discusses recent efforts to translate fundamental discovery from the laboratory into the clinic, and provides an outlook on future research aimed at harnessing the full therapeutic potential of the SNA platform.
Journal ArticleDOI
Nucleic acid-based supramolecular structures: vesicular spherical nucleic acids from a non-phospholipid nucleolipid
Erik Dimitrov,Natalia Toncheva-Moncheva,Pavel Bakardzhiev,Aleksander Forys,Jordan Doumanov,Kirilka Mladenova,Svetla Petrova,Barbara Trzebicka,Stanislav Rangelov +8 more
TL;DR: The vesicular structures were shown to exhibit cellular internalization with no need of transfection agents and enhanced colloidal and nuclease stability, and were compared to those of reference spherical nucleic acids.
Journal ArticleDOI
Two-dimensional structures formed in a binary system of DNA nanoparticles with a short-range interaction potential
TL;DR: In this article, the authors carried out Brownian dynamics simulations and studied the formation of two-dimensional structures in a binary system, where different types of particles attract each other with Morse potential, which is minimum when their distance is σ'.
Journal ArticleDOI
Enzymatically Controlled Vacancies in Nanoparticle Crystals
Stacey N. Barnaby,Michael B. Ross,Ryan V. Thaner,Byeongdu Lee,George C. Schatz,Chad A. Mirkin +5 more
TL;DR: The bonding elements of nanoparticle crystals can be enzymatically and selectively addressed without affecting the nature of the atom, which is not possible in atomic systems, through the use of DNA and RNA bonding elements.
References
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In vivo cancer targeting and imaging with semiconductor quantum dots
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Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.