Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Inverting the design path for self-assembled block copolymers
TL;DR: This review examines recent advances of inverse design methods in soft materials containing block copolymers, colloids, or DNA by combining well-developed theoretical models with advanced inverse search algorithms.
Journal ArticleDOI
PAMAM dendrimers as quantized building blocks for novel nanostructures
TL;DR: In this work, click-functional ligands are stochastically conjugated to monomeric generation 5 PAMAM dendrimer and separated via reverse-phase HPLC to isolatedendrimers with precise numbers of click ligands per dendricer particle, which are employed as modular building blocks for the synthesis of defined nanostructures.
Journal Article
Highly tunable gold nanorod dimer resonances mediated through conductive junctions
Jake Fontana,Banahalli R. Ratna +1 more
TL;DR: In this article, the optical properties of gold nanorod (Au NR) dimers connected end-to-end by a thin metallic junction were studied and it was shown that the charge transfer plasmon absorbance peak shift from the dimer structure is proportional to the NR aspect ratio.
Journal ArticleDOI
Three-dimensional molecular and nanoparticle crystallization by DNA nanotechnology
Nadrian C. Seeman,Oleg Gang +1 more
TL;DR: A review of the development of 3D assembly of DNA and DNA-guided nanoparticle arrays, the issues that have prevented and facilitated formation of such structures, and recent strategies toward this goal can be found in this paper.
Journal ArticleDOI
Uniform Distance Scaling Behavior of Planet-Satellite Nanostructures Made by Star Polymers.
TL;DR: These findings demonstrate the feasibility to precisely control the planet-satellite structures at the nanoscale and show that these distances are controlled by the density of star polymers end groups, and the number of grabbed satellite particles is determined by the magnitude of the corresponding density.
References
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A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
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In vivo cancer targeting and imaging with semiconductor quantum dots
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Journal ArticleDOI
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.