Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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PatentDOI
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
TL;DR: In this article, the authors demonstrate that G-rich spherical nucleic acid (SNAs) exhibit several-fold higher uptake into cells relative to SNAs rich in other nucleotides.
Journal ArticleDOI
Multi-component superstructures self-assembled from nanocrystal building blocks
TL;DR: This minireview summarizes recent advances in the synthetic strategies and superstructures of this multi-component metamaterial, and highlights their novel properties and potential applications.
Journal ArticleDOI
Hydrodynamics selects the pathway for displacive transformations in DNA-linked colloidal crystallites
TL;DR: It is found that hydrodynamic correlations between particles result in anisotropic mobility along the various possible displacive pathways, strongly selecting for pathways that lead to the fcc-CuAu-I configuration, explaining recent experimental observations.
Journal ArticleDOI
Preparation and Self-Assembly of Dendronized Janus Fe3O4-Pt and Fe3O4-Au Heterodimers
TL;DR: The preparation of Janus heterodimers via asymmetric functionalization of Fe3O4-Pt and Fe3 O4-Au heterodimeric NPs is demonstrated, showing a drastic improvement in film crystallinity and suggesting the dendronization induced improvement of the whole particle polydispersity of the heterodIMers.
Journal ArticleDOI
Precise organization of metal nanoparticles on DNA origami template.
TL;DR: This review aims to summarize the methods that use DNA origami structures as templates to precisely organize metal nanoparticles, such as gold nanospheres, gold nanorods and silver nanoparticles (AgNPs), and the potential applications and the perspective are discussed.
References
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Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
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