Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Journal ArticleDOI
Programmable materials and the nature of the DNA bond
TL;DR: The two main approaches to creating stiff bonds, based on DNA-based materials synthesis, are reviewed, offering perhaps the most versatile way of organizing optically active materials into architectures that exhibit unusual and deliberately tailorable plasmonic and photonic properties.
Journal ArticleDOI
DNA Nanotechnology-Enabled Drug Delivery Systems
TL;DR: The origin of DNA nanotechnology is reviewed, followed by summarizing state-of-the-art strategies for the construction of DNAnanostructures and drug payloads delivered by DNA nanovehicles and challenges and opportunities for DNA nanostructure-based drug delivery.
Journal ArticleDOI
The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles.
Amelie Heuer-Jungemann,Neus Feliu,Neus Feliu,Ioanna Bakaimi,Majd A. Hamaly,Alaaldin M. Alkilany,Alaaldin M. Alkilany,Indranath Chakraborty,Atif Masood,Maria Francesca Casula,Athanasia Kostopoulou,Eunkeu Oh,Kimihiro Susumu,Michael H. Stewart,Igor L. Medintz,Emmanuel Stratakis,Wolfgang J. Parak,Antonios G. Kanaras +17 more
TL;DR: This article analyzes the interaction of nanoparticle surface and ligands with different chemical groups, the types of bonding, the final dispersibility of ligand-coated nanoparticles in complex media, their reactivity, and their performance in biomedicine, photodetectors, photovoltaic devices, light-emitting devices, sensors, memory devices, thermoelectric applications, and catalysis.
Journal ArticleDOI
Small Angle X-ray Scattering for Nanoparticle Research
TL;DR: This work provides a theoretical foundation for X-ray scattering, considering both form factor and structure factor, as well as the use of correlation functions, which may be used to determine a particle's size, size distribution, shape, and organization into hierarchical structures.
Journal ArticleDOI
DNA-mediated nanoparticle crystallization into Wulff polyhedra
Evelyn Auyeung,Ting I. N. G. Li,Andrew J. Senesi,Abrin L. Schmucker,Bridget C. Pals,Monica Olvera de la Cruz,Chad A. Mirkin +6 more
TL;DR: Very slow cooling, over several days, of solutions of complementary-DNA-modified nanoparticles through the melting temperature of the system gives the thermodynamic product with a specific and uniform crystal habit, thus establishing that DNA hybridization can direct nanoparticle assembly along a pathway that mimics atomic crystallization.
References
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Journal ArticleDOI
Synthesis and Characterization of Monodisperse Nanocrystals and Close-Packed Nanocrystal Assemblies
TL;DR: In this article, solution phase syntheses and size-selective separation methods to prepare semiconductor and metal nanocrystals, tunable in size from ∼1 to 20 nm and monodisperse to ≤ 5%, are presented.
Journal ArticleDOI
Prospects of Colloidal Nanocrystals for Electronic and Optoelectronic Applications
TL;DR: Nanocrystals (NCs) discussed in this Review are tiny crystals of metals, semiconductors, and magnetic material consisting of hundreds to a few thousand atoms each that are among the hottest research topics of the last decades.
Journal ArticleDOI
A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems
TL;DR: A strain-promoted [3 + 2] cycloaddition between cyclooctynes and azides that proceeds under physiological conditions without the need for a catalyst was demonstrated by selective modification of biomolecules in vitro and on living cells, with no apparent toxicity.
Journal ArticleDOI
DNA-guided crystallization of colloidal nanoparticles
TL;DR: The formation of three-dimensional crystalline assemblies of gold nanoparticles mediated by interactions between complementary DNA molecules attached to the nanoparticles’ surface is reported, and it is found that the nanoparticle crystals form reversibly during heating and cooling cycles.
Journal ArticleDOI
What controls the melting properties of DNA-linked gold nanoparticle assemblies?
TL;DR: A series of experiments and a theoretical model designed to systematically define and evaluate the relative importance of nanoparticle, oligonucleotide, and environmental variables that contribute to the observed sharp melting transitions associated with DNA-linked nanoparticle structures are reported.