Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Journal ArticleDOI
The Role of Repulsion in Colloidal Crystal Engineering with DNA
TL;DR: A mean-field model that provides a mathematical description for the observed trend of repulsive interactions in DNA-NP superlattices shows that the trend is due to the variation in the effective cross-sectional diameter of DNA duplex and the thickness of DNA shell.
Journal ArticleDOI
Binary Superlattice Design by Controlling DNA-Mediated Interactions
TL;DR: In this article, a strategy that leverages the tunable disparity in interparticle interactions, and thus enthalpic driving forces, to open new avenues for design of binary superlattices that do not rely on the ability to tune particle size (i.e., entropic driving forces).
Journal ArticleDOI
Programming macro-materials from DNA-directed self-assembly
Xuena Zhang,Rong Wang,Gi Xue +2 more
TL;DR: Recent experimental and theoretical developments of DNA-programmable self-assembly into three-dimensional (3D) materials are summarized and various types of aggregates and 3D crystal structures obtained from an experimental DNA-driven assembly are introduced.
Journal ArticleDOI
Self-Assembly of Quantum Dot–Gold Heterodimer Nanocrystals with Orientational Order
Hua Zhu,Zhaochuan Fan,Yucheng Yuan,Mitchell A. Wilson,Katie Hills-Kimball,Zichao Wei,Jie He,Ruipeng Li,Michael Grünwald,Ou Chen +9 more
TL;DR: The synthesis of quantum dot-gold (QD-Au) heterodimers is demonstrated, which results in a superlattice with long-range orientational alignment of dimers and is a potential route to nanomaterials with useful optoelectronic properties.
Journal ArticleDOI
Optical properties and electronic transitions of DNA oligonucleotides as a function of composition and stacking sequence
Jacob Schimelman,Daniel M. Dryden,Lokendra Poudel,Katherine E. Krawiec,Yingfang Ma,Rudolf Podgornik,Rudolf Podgornik,Rudolf Podgornik,V. Adrian Parsegian,Linda K. Denoyer,Wai-Yim Ching,Nicole F. Steinmetz,Roger H. French +12 more
TL;DR: The results highlight the benefit of full spectral analysis of DNA, as opposed to reductive methods that consider only the 260 nm absorbance or simple purity ratios, and suggest that the slope of the absorption edge onset may provide a useful metric for the degree of base pair stacking in DNA.
References
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A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
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In vivo cancer targeting and imaging with semiconductor quantum dots
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Journal ArticleDOI
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.