Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Journal ArticleDOI
Stepwise Assembly and Characterization of DNA Linked Two-Color Quantum Dot Clusters.
TL;DR: The results indicate that a significant amount of QD- to-QD energy transfer occurred in the clusters, which was studied as a function of increasing acceptor-to-donor ratios, resulting in increased QD acceptor emission intensities compared to controls.
Journal ArticleDOI
Conformal, Macroscopic Crystalline Nanoparticle Sheets Assembled with DNA
TL;DR: A novel method for preparing conformal silica-embedded crystalline nanoparticle sheets via DNA programmable assembly provides independent control over nanoparticle size, nanoparticle spacing, and film thickness.
Journal ArticleDOI
Optical Processing of DNA-Programmed Nanoparticle Superlattices.
TL;DR: The interplay of structure-directing forces at multiple length scales is investigated by utilizing optical processing to influence both nanoscale and microscale features of self-assembled, DNA-grafted nanoparticle films.
Journal ArticleDOI
Self-assembled peptide nanoparticles with endosome escaping permits for co-drug delivery.
Yingshu Guo,Yingshu Guo,Yinhua Hu,Xiaofei Zheng,Xiuping Cao,Qiong Li,Zhiyong Wei,Zhenkai Zhu,Shusheng Zhang +8 more
TL;DR: The proposed multi-functional nanoparticles have initiated new ideas for these hybrid anticancer drugs based on peptide self-assembled nanocarriers and its widely applications in biomedicine.
Journal ArticleDOI
Controlling Crystal Texture in Programmable Atom Equivalent Thin Films.
TL;DR: This study investigates the pathway through which DNA- functionalized nanoparticles bound to a DNA-functionalized substrate reorganize upon annealing to synthesize superlattice thin films with restricted orientation, highlighting the remarkable interplays between nanoscale building blocks and mesoscale orientation, and expands the structure-defining capabilities of DNA-grafted nanoparticles.
References
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A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
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In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
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Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.