Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Journal ArticleDOI
Programmable materials and the nature of the DNA bond
TL;DR: The two main approaches to creating stiff bonds, based on DNA-based materials synthesis, are reviewed, offering perhaps the most versatile way of organizing optically active materials into architectures that exhibit unusual and deliberately tailorable plasmonic and photonic properties.
Journal ArticleDOI
DNA Nanotechnology-Enabled Drug Delivery Systems
TL;DR: The origin of DNA nanotechnology is reviewed, followed by summarizing state-of-the-art strategies for the construction of DNAnanostructures and drug payloads delivered by DNA nanovehicles and challenges and opportunities for DNA nanostructure-based drug delivery.
Journal ArticleDOI
The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles.
Amelie Heuer-Jungemann,Neus Feliu,Neus Feliu,Ioanna Bakaimi,Majd A. Hamaly,Alaaldin M. Alkilany,Alaaldin M. Alkilany,Indranath Chakraborty,Atif Masood,Maria Francesca Casula,Athanasia Kostopoulou,Eunkeu Oh,Kimihiro Susumu,Michael H. Stewart,Igor L. Medintz,Emmanuel Stratakis,Wolfgang J. Parak,Antonios G. Kanaras +17 more
TL;DR: This article analyzes the interaction of nanoparticle surface and ligands with different chemical groups, the types of bonding, the final dispersibility of ligand-coated nanoparticles in complex media, their reactivity, and their performance in biomedicine, photodetectors, photovoltaic devices, light-emitting devices, sensors, memory devices, thermoelectric applications, and catalysis.
Journal ArticleDOI
Small Angle X-ray Scattering for Nanoparticle Research
TL;DR: This work provides a theoretical foundation for X-ray scattering, considering both form factor and structure factor, as well as the use of correlation functions, which may be used to determine a particle's size, size distribution, shape, and organization into hierarchical structures.
Journal ArticleDOI
DNA-mediated nanoparticle crystallization into Wulff polyhedra
Evelyn Auyeung,Ting I. N. G. Li,Andrew J. Senesi,Abrin L. Schmucker,Bridget C. Pals,Monica Olvera de la Cruz,Chad A. Mirkin +6 more
TL;DR: Very slow cooling, over several days, of solutions of complementary-DNA-modified nanoparticles through the melting temperature of the system gives the thermodynamic product with a specific and uniform crystal habit, thus establishing that DNA hybridization can direct nanoparticle assembly along a pathway that mimics atomic crystallization.
References
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Journal ArticleDOI
Recent Advances in Chemical Synthesis, Self‐Assembly, and Applications of FePt Nanoparticles
TL;DR: In this paper, a review of recent advances in chemical synthesis, self-assembly, and potential applications of monodisperse binary FePt nanoparticles is presented. And the surface, structural, and magnetic properties of these nanoparticles are discussed, along with three potential applications in data storage, permanent magnetic nanocomposites, and biomedicine.
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Superparamagnetic Colloids: Controlled Synthesis and Niche Applications**
TL;DR: A comprehensive review of superparamagnetic colloid research can be found in this article, with a focus on those systems that can be prepared as monodisperse samples and in relatively large quantities.
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Spherical Nucleic Acids
TL;DR: This Perspective details the synthetic methods for preparing spherical nucleic acid conjugates, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Journal ArticleDOI
DNA-nanoparticle superlattices formed from anisotropic building blocks
Matthew R. Jones,Robert J. Macfarlane,Byeongdu Lee,Jian Zhang,Kaylie L. Young,Andrew J. Senesi,Chad A. Mirkin +6 more
TL;DR: The concept of inherent shape-directed crystallization in the context of DNA-mediated nanoparticle assembly is examined and it is shown how the anisotropy of these particles can be used to synthesize one- and three-dimensional structures that cannot be made through the assembly of spherical particles.