Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Journal ArticleDOI
DNA-Nanoparticle Tinkertoys.
TL;DR: The molecular recognition properties and the robustness of designed DNA nanostructures have been used in combination with metallic nanoparticles for the production of the elusive diamond superlattice.
Journal ArticleDOI
Self-assembly of Pt nanocrystals into three-dimensional superlattices results in enhanced electrocatalytic performance for methanol oxidation
TL;DR: In this paper, a simple and low-temperature solution approach without the need of any preformed Pt seeds was developed to directly realize a series of 3D Pt nanocrystal superlattices (NSLs) composed of well-defined interior Pt nanoparticles assembled into 3D face-centered cubic (fcc) structures.
Journal ArticleDOI
Highly Efficient AuPd Catalyst for Synthesizing Polybenzoxazole with Controlled Polymerization
Chao Yu,Xuefeng Guo,Zhouyang Yin,Zhonglong Zhao,Xing Li,Jerome R. Robinson,Michelle Muzzio,Cintia J. Castilho,Mengqi Shen,Yucheng Yuan,Junyu Wang,John Antolik,Gang Lu,Dong Su,Ou Chen,Pradeep R. Guduru,Christopher T. Seto,Shouheng Sun +17 more
TL;DR: In this paper, an active and stable catalyzed one-pot reaction of formic acid, 1,5-diisopropoxy-2,4-dinitrobenzene, and terephthaldehyde, leading to the controlled polymerization and the formation of polybenzoxazole (PBO) was reported.
Journal ArticleDOI
Quantum dots in proteomic studies and medical diagnostics
TL;DR: This review is devoted to the description of in vitro proteomic approaches used in the studies and diagnostics, where the problem related to toxicity is not as crucial as in therapy and no restrictions on the types and composition of QDs are imposed.
Patent
Lipophilic nanoparticles for drug delivery
TL;DR: Nanostructures having a core, a lipid layer and a lipoprotein which are useful for delivering therapeutic agents are provided in this article, including methods of treating cancer, infectious disease, vascular disease etc.
References
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A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
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Journal ArticleDOI
In vivo cancer targeting and imaging with semiconductor quantum dots
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Journal ArticleDOI
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.