Journal ArticleDOI
A general approach to DNA-programmable atom equivalents
Chuan Zhang,Robert J. Macfarlane,Kaylie L. Young,Chung Hang Jonathan Choi,Liangliang Hao,Evelyn Auyeung,Guoliang Liu,Xiaozhu Zhou,Chad A. Mirkin +8 more
TLDR
By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.Abstract:
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled. However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.read more
Citations
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Journal ArticleDOI
Catalytic-assembly of programmable atom equivalents.
Dongbao Yao,Yunhan Zhang,Xiang Zhou,Xiaoyun Sun,Xiaoyu Liu,Junxiang Zhou,Wei Jiang,Wenqiang Hua,Haojun Liang +8 more
TL;DR: In this paper , a removable molecule named "catassembler" was employed to rectify imperfect linkages and help the system escape from metastability without affecting the assembled framework, which opens up an avenue for programming colloid assembly in a far-from-equilibrium system.
Journal ArticleDOI
A Reconfigurable Nanophotonic Heterostructure Engineered by a DNA Origami Switch.
TL;DR: This work constructed a reconfigurable nanophotonic heterostructure by integrating an upconversion nanoparticle (UCNP) and a gold nanorod (AuNR) on a DNA origami switch (DOS) template that can be excited by 980 laser light and generates visible light emission.
Overcoming Temozolomide Resistance in Glioblastoma Multiforme with MGMT-Targeting Spherical Nucleic Acids
TL;DR: Using siRNA-based therapy to overcome TMZ resistance in glioblastoma multiforme cells with ribozyme-SNAs and in vivo limitations of siRNA therapeutics is proposed.
Nucleic acid programmed polymeric nanomaterials for biological communication
TL;DR: These materials represent a unique class of DNA delivery system capable of rendering nucleic acids with natural backbone chemistry resistant to nuclease degradation and further serving to deliver DNA into cells to facilitate depletion of mRNA levels in a sequence- specific fashion.
Journal ArticleDOI
Magnetically controlled anisotropic light emission of DNA-functionalized supraparticles
Talha Erdem,Mykolas Zupkauskas,Thomas O'Neill,Alessio Cassiagli,Peicheng Xu,Yemliha Altintas,Evren Mutlugun,Erika Eiser +7 more
TL;DR: In this article , a proof-of-concept scheme to control the optical features of a self-assembled supraparticle system using an external interaction was presented, where single-stranded DNA molecules were attached to the supraparticles of semiconductor, metal, and magnetic nanoparticles to tailor optical features.
References
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