A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.
Toshio Matsumoto,Masako Ito,Yasufumi Hayashi,Takako Hirota,Yusuke Tanigawara,Teruki Sone,Masao Fukunaga,Masataka Shiraki,Toshitaka Nakamura +8 more
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TLDR
Eldecalcitol is more efficacious in preventing vertebral and wrist fractures in osteoporotic patients with vitamin D sufficiency, with a safety profile similar to alfacalcidol.About:
This article is published in Bone.The article was published on 2011-10-01 and is currently open access. It has received 153 citations till now. The article focuses on the topics: Eldecalcitol & Alfacalcidol.read more
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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
TL;DR: The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange, which will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications.
Journal ArticleDOI
Japanese 2011 guidelines for prevention and treatment of osteoporosis--executive summary
Hajime Orimo,Toshitaka Nakamura,Takayuki Hosoi,Masayuki Iki,Kazuhiro Uenishi,Naoto Endo,Hiroaki Ohta,Masataka Shiraki,Toshitsugu Sugimoto,Takao Suzuki,Satoshi Soen,Yoshiki Nishizawa,Hiroshi Hagino,Masao Fukunaga,Saeko Fujiwara +14 more
TL;DR: The present guidelines provide information for the managements of primary osteoporosis in postmenopausal women and men over 50 years old, a summary of the evidence for the treatment of secondary osteopsorosis, and a summary for the prevention of osteoporeosis in younger people.
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Vitamin D, calcium homeostasis and aging
TL;DR: An overview of the current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented and mechanism involved in age-related dysregulation of 1,25(OH)2D3 action is reviewed.
Journal ArticleDOI
Vitamin D Receptor in Osteoblasts Is a Negative Regulator of Bone Mass Control
Yoko Yamamoto,Tatsuya Yoshizawa,Toru Fukuda,Yuko Shirode-Fukuda,Taiyong Yu,Keisuke Sekine,Takashi Sato,Hirotaka Kawano,Ken-ichi Aihara,Yuko Nakamichi,Tomoyuki Watanabe,Masayo Shindo,Kazuki Inoue,Erina Inoue,Naoya Tsuji,Maiko Hoshino,Gerard Karsenty,Daniel Metzger,Pierre Chambon,Shigeaki Kato,Yuuki Imai +20 more
TL;DR: Findings establish that VDR in osteoblasts is a negative regulator of bone mass control and plays a role in bone mass regulation.
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The future of vitamin D analogs
TL;DR: An overview of the action of vitamin D analogs in tumor cells is given and how these compounds could be introduced in the clinical practice is looked forward.
References
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Vertebral fracture assessment using a semiquantitative technique
TL;DR: The semiquantitative approach can be applied reliably in vertebral fracture assessment when performed using well‐defined criteria, and this approach was compared with a quantitative morpho‐metric approach.
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Effect of Vitamin D on falls: a meta-analysis
Heike A. Bischoff-Ferrari,Bess Dawson-Hughes,Walter C. Willett,Hannes B. Staehelin,Marlet G. Bazemore,Robert Y. Zee,John B. Wong +6 more
TL;DR: Vitamin D supplementation appears to reduce the risk of falls among ambulatory or institutionalized older individuals with stable health by more than 20%.
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Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
Heike A. Bischoff-Ferrari,Bess Dawson-Hughes,Hannes B. Staehelin,John Orav,Andreas E. Stuck,Robert Theiler,John B. Wong,Andreas Egli,Douglas P. Kiel,Jana Henschkowski,Jana Henschkowski +10 more
TL;DR: Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D.
Journal ArticleDOI
Treatment of postmenopausal osteoporosis with calcitriol or calcium
TL;DR: Women who received calcitriol had a significant reduction in the rate of new vertebral fractures during the second and third years of treatment, as compared with the women who received calcium.
Meta-Analyses of Therapies for Postmenopausal Osteoporosis
Ann Cranney,Peter Tugwell,George Wells,Andrew R. Willan,Lauren Griffith,Nicole Zytaruk,Vivian Robinson,Dennis M. Black,Jonathan,Beverley Shea,Gordon H. Guyatt,Jonathan D. Adachi,Bruce Weaver,Alexandra Papaioannou,V. Hormone Replacement,Joan Peterson,David Henry +16 more
TL;DR: The Osteoporosis Methodology Group’s findings and recommendations will help improve the quality of clinical trials and improve the prognosis for patients with suspected oesophageal cancer.