Journal ArticleDOI
A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling.
Dmitry Kovalenko,Xuehui Yang,Pei-Yu Chen,Pei-Yu Chen,Robert J. Nadeau,Robert J. Nadeau,Olga Zubanova,Kathleen Pigeon,Robert Friesel,Robert Friesel +9 more
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TLDR
It is demonstrated that both extracellular and transmembrane domains of Sef contributed to Sef-mediated negative regulation of FGF signaling, and that SefECTM reduced cell viability when over-expressed in human umbilical vein endothelial cells (HUVEC).About:
This article is published in Cellular Signalling.The article was published on 2006-11-01. It has received 37 citations till now. The article focuses on the topics: MAPK/ERK pathway & Tyrosine phosphorylation.read more
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The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
Journal ArticleDOI
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter.
Maria Ekerot,Marios P. Stavridis,Laurent Delavaine,Michael Mitchell,Christopher J. Staples,David M. Owens,Iain D. Keenan,Robin J. Dickinson,Kate G. Storey,Stephen M. Keyse +9 more
TL;DR: Findings identify a conserved Ets-factor-dependent mechanism by which ERK signalling activates DUSP6/MKP-3 transcription to deliver ERK1/2-specific negative-feedback control of FGF signalling.
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BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
Libbat Tirosh-Finkel,Amit Zeisel,Miriam Brodt-Ivenshitz,Ayelet Shamai,Zhong Yao,Rony Seger,Eytan Domany,Eldad Tzahor +7 more
TL;DR: The anterior heart field (AHF) encompasses a niche in which mesoderm-derived cardiac progenitors maintain their multipotent and undifferentiated nature in response to signals from surrounding tissues, and tight crosstalk between bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) signaling pathways within the AHF niche is revealed.
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TGF-β Family Signaling in Early Vertebrate Development
TL;DR: In this article, the authors summarize the current knowledge of the function and regulation of TGF-β family signaling in these processes and focus specifically on three popular model organisms: the mouse Mus musculus, the African clawed frog of the genus Xenopus and the zebrafish Danio rerio, highlighting the similarities and differences between these species.
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Fibroblast Growth Factor Signaling in the Vasculature
Xuehui Yang,Lucy Liaw,Igor Prudovsky,Peter C. Brooks,Calvin P.H. Vary,Leif Oxburgh,Robert Friesel +6 more
TL;DR: A review of recent studies in which new and unanticipated roles for FGFs and their receptors in the vasculature have been revealed is summarized.
References
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Journal ArticleDOI
Fibroblast growth factors, their receptors and signaling.
TL;DR: FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.
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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
TL;DR: The results indicate that Ras functions as a regulated, membrane-bound anchor for Raf, and that other signal(s) also contribute to Raf activation.
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Construction of adenovirus vectors through Cre-lox recombination.
TL;DR: First, a simple method for constructing E1-substituted adenovirus vectors carrying recombinant genes in place of all of the viral genes is demonstrated, so-called gutless adenOVirus vectors.
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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.
David M. Ornitz,Pierre J. Marie +1 more
TL;DR: The role of FGF signaling in bone development and in human genetic diseases that affect bone development is examined and what is presently known about how FGF signalling pathways interact with other major signaling pathways that regulate chondrogenesis and osteogenesis is explored.
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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
H. Kouhara,Y. R. Hadari,T Spivak-Kroizman,J Schilling,Dafna Bar-Sagi,Irit Lax,Joseph Schlessinger +6 more
TL;DR: It is found that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation.