A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Monika A. Niewczas,Monika A. Niewczas,Meda E. Pavkov,Jan Skupien,Jan Skupien,Adam M. Smiles,Zaipul I. Md Dom,Zaipul I. Md Dom,Jonathan M. Wilson,Jihwan Park,Viji Nair,Andrew Schlafly,Pierre-Jean Saulnier,Pierre-Jean Saulnier,Eiichiro Satake,Eiichiro Satake,Christopher A Simeone,Hetal Shah,Hetal Shah,Chengxiang Qiu,Helen C. Looker,Paolo Fiorina,Paolo Fiorina,Carl F. Ware,Jennifer K. Sun,Jennifer K. Sun,Alessandro Doria,Alessandro Doria,Matthias Kretzler,Katalin Susztak,Kevin L. Duffin,Robert G. Nelson,Andrzej S. Krolewski,Andrzej S. Krolewski +33 more
Reads0
Chats0
TLDR
These findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying end-stage renal disease development in both types of diabetes, and point to new therapeutic targets and new prognostic tests to identify subjects at risk of end-Stage renal disease.Abstract:
Chronic inflammation is postulated to be involved in the development of end-stage renal disease in diabetes, but which specific circulating inflammatory proteins contribute to this risk remain unknown. To study this, we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with type 1 and type 2 diabetes. In each cohort, we identified an extremely robust kidney risk inflammatory signature (KRIS), consisting of 17 proteins enriched in tumor necrosis factor-receptor superfamily members, that was associated with a 10-year risk of end-stage renal disease. All these proteins had a systemic, non-kidney source. Our prospective study findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying end-stage renal disease development in both types of diabetes. These proteins point to new therapeutic targets and new prognostic tests to identify subjects at risk of end-stage renal disease, as well as biomarkers to measure responses to treatment of diabetic kidney disease.read more
Citations
More filters
Journal ArticleDOI
Targeting the progression of chronic kidney disease
TL;DR: The authors review drivers of fibrogenesis, including epithelial cell injury, inflammation, regeneration pathways and factors that promote the AKI-to-CKD transition, and discuss direct targeting of fibrotic pathways and therapeutic approaches that have reportedly decreased kidney fibrosis in preclinical and/or clinical studies.
Journal ArticleDOI
The single-cell transcriptomic landscape of early human diabetic nephropathy
Parker C. Wilson,Haojia Wu,Yuhei Kirita,Kohei Uchimura,Nicolas Ledru,Helmut G. Rennke,Paul A. Welling,Sushrut S. Waikar,Benjamin D. Humphreys +8 more
TL;DR: Increased potassium secretion and angiogenic signaling represent early kidney responses in human diabetic nephropathy, and are suggested to be important for ion transport, angiogenesis, and immune cell activation.
Journal ArticleDOI
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
Ki Wung Chung,Poonam Dhillon,Shizheng Huang,Xin Sheng,Rojesh Shrestha,Chengxiang Qiu,Brett A. Kaufman,Jihwan Park,Liming Pei,Liming Pei,Joseph A. Baur,Matthew Palmer,Katalin Susztak +12 more
TL;DR: Ablation of STING ameliorated kidney fibrosis in mouse models of chronic kidney disease, demonstrating how TFAM sequesters mtDNA to limit the inflammation leading to fibrosis.
Journal ArticleDOI
Innate immunity in diabetic kidney disease.
Sydney C.W. Tang,Wai Han Yiu +1 more
TL;DR: The authors discuss the mechanisms by which innate immune pathways might contribute to DKD as well as the therapeutic potential of targeting these pathways.
Journal ArticleDOI
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection.
Laura Montefusco,Moufida Ben Nasr,Moufida Ben Nasr,Francesca D'Addio,Cristian Loretelli,Antonio Rossi,Ida Pastore,Giuseppe Daniele,Ahmed Abdelsalam,Anna Maestroni,Marco Dell’Acqua,Elio Ippolito,Emma Assi,Vera Usuelli,Andy Joe Seelam,Roberta Maria Fiorina,Enrica Chebat,Paola Morpurgo,Maria Elena Lunati,Andrea Mario Bolla,Giovanna Finzi,Reza Abdi,Joseph V. Bonventre,Stefano Rusconi,Agostino Riva,Domenico Corradi,Pierachille Santus,Manuela Nebuloni,Franco Folli,Gian Vincenzo Zuccotti,Massimo Galli,Paolo Fiorina,Paolo Fiorina +32 more
TL;DR: In this paper, abnormalities in glycometabolic control, insulin resistance and beta cell function in patients with COVID-19 without any pre-existing history or diagnosis of diabetes, and document glycaemic abnormalities in recovered patients 2 months after onset of disease.
References
More filters
Journal ArticleDOI
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
Craig Tuerk,Larry Gold +1 more
TL;DR: High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species.
Journal ArticleDOI
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Paul M. Ridker,Brendan M. Everett,Tom Thuren,Jean G. MacFadyen,William Chang,Christie M. Ballantyne,Francisco H. Fonseca,Jose C. Nicolau,Wolfgang Koenig,Stefan D. Anker,John J.P. Kastelein,Jan H. Cornel,Prem Pais,Daniel Pella,Jacques Genest,Renata Cifkova,Alberto J. Lorenzatti,Tamás Forster,Zhanna Kobalava,Luminita Vida-Simiti,Marcus Flather,Hiroaki Shimokawa,Hisao Ogawa,Mikael Dellborg,Paulo Roberto Ferreira Rossi,Roland P.T. Troquay,Peter Libby,Robert J. Glynn +27 more
TL;DR: Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Journal ArticleDOI
The TNF and TNF receptor superfamilies: integrating mammalian biology.
TL;DR: The authors regret the inability to cite all of the primary literature contributing to this review due to length considerations, but wish to thank F. Chan, T. Migone, and J. Wang for insightful comments on the manuscript.
Journal ArticleDOI
Data, information, knowledge and principle: back to metabolism in KEGG
TL;DR: The reaction modules, which represent chemical units of reactions, have been used to analyze design principles of metabolic networks and also to improve the definition of K numbers and associated annotations for translational bioinformatics.
Journal ArticleDOI
Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros.
TL;DR: The developments in mediation analysis for nonlinear models within the counterfactual framework within the psychology audience is brought to an accessible format and the types of inferences about mediation that are allowed by a variety of software macros are compared.
Related Papers (5)
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Vlado Perkovic,Vlado Perkovic,Meg Jardine,Meg Jardine,Bruce Neal,Bruce Neal,Bruce Neal,Severine Bompoint,Hiddo J.L. Heerspink,David M. Charytan,David M. Charytan,Robert Edwards,Rajiv Agarwal,Rajiv Agarwal,George L. Bakris,Scott Bull,Christopher P. Cannon,Christopher P. Cannon,George Capuano,Pei-Ling Chu,Dick de Zeeuw,Tom Greene,Adeera Levin,Carol A. Pollock,David C. Wheeler,Yshai Yavin,Hong Zhang,Bernard Zinman,Gary Meininger,Barry M. Brenner,Kenneth W. Mahaffey +30 more