A single-dose combination therapy that both prevents and treats anthrax infection.
Dennis M. Klinman,Debra Tross +1 more
TLDR
Results show that significant protection is achieved by delivering a single dose of a long-acting antibiotic (Dalbavancin) combined with a rapidly immunogenic vaccine/adjuvant combination any time before through 3 days after anthrax exposure.About:
This article is published in Vaccine.The article was published on 2009-03-13 and is currently open access. It has received 22 citations till now. The article focuses on the topics: Anthrax vaccines & Anthrax Vaccine Adsorbed.read more
Citations
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Journal ArticleDOI
TLR-based immune adjuvants.
TL;DR: The nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants are described and those agents for which clinical results are available are reviewed.
Journal ArticleDOI
Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers.
Dianna Rynkiewicz,Melinda Rathkopf,Iain Sim,A. Thomas Waytes,Robert J. Hopkins,Lallan Giri,Deborah DeMuria,Janet Ransom,James Quinn,Gary S. Nabors,Carl J. Nielsen +10 more
TL;DR: The marked acceleration and enhancement of the immune response seen by combining BioThrax and CPG 7909 offers the potential to shorten the course of immunization and reduce the time to protection, and may be particularly useful in the setting of post-exposure prophylaxis.
Journal ArticleDOI
Anthrax: an update.
TL;DR: The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene, and administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90%-100% survival.
Journal ArticleDOI
In situ gastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli
TL;DR: Lactobacilli expressing a neutralising scFv fragment against the PA antigen of the anthrax toxin, which can provide protection against anthrax toxins both in vitro and in vivo are developed.
Journal ArticleDOI
A fucoidan-quaternary chitosan nanoparticle adjuvant for anthrax vaccine as an alternative to CpG oligodeoxynucleotides.
Chuan-chang Chuang,Meng-Hung Tsai,Hui-ju Yen,Huey-Fen Shyu,Kuang-ming Cheng,Xin-an Chen,Cheng-Cheung Chen,Jenn-jong Young,Jyh-Hwa Kau +8 more
TL;DR: The findings support FUC-HTCC NPs as a potential adjuvant of AVA for rapid induction of protective immunity and combine with AVA significantly increases the magnitude of IgG-anti-protective antigen titers in A/J mice.
References
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Journal ArticleDOI
A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
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Cpg motifs in bacterial dna trigger direct b-cell activation
Arthur M. Krieg,Ae-Kyung Yi,Sara Matson,Thomas J. Waldschmidt,Gail A. Bishop,Gail A. Bishop,Rebecca M. Teasdale,Gary A. Koretzky,Dennis M. Klinman +8 more
TL;DR: The potent immune activation by CpG oligon nucleotides has impli-cations for the design and interpretation of studies using 'antisense' oligonucleotides and points to possible new applications as adjuvants.
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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
TL;DR: Stimulatory CpG DNA motifs induced B, T, and natural killer cells to secrete cytokine more effectively than did lipopolysaccharide, suggesting immune recognition of bacterial DNA may contribute to the cytokine, as well as the antibody production characteristic of an innate inflammatory response.
Journal ArticleDOI
How Often Is Medication Taken as Prescribed?: A Novel Assessment Technique
TL;DR: Using a new method with epilepsy as a model, compliance with long-term medications among newly treated and long- term patients is assessed using standard pill bottles with micro-processors in the cap to record every bottle opening as a presumptive dose.
Journal Article
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.
TL;DR: It is demonstrated that CpG motifs contained in ODN as short as 15 bases in length were quite effective at inducing NK cell lytic activity in vitro in both human and murine lymphocytes.