A systematic review of tests to predict cerebral palsy in young children.
Margot Bosanquet,Margot Bosanquet,Margot Bosanquet,Lisa Copeland,Robert S. Ware,Robert S. Ware,Roslyn N. Boyd,Roslyn N. Boyd +7 more
TLDR
This systematic review evaluates the accuracy of predictive assessments and investigations used to assist in the diagnosis of cerebral palsy in preschool‐age children (<5y).Abstract:
Aim
This systematic review evaluates the accuracy of predictive assessments and investigations used to assist in the diagnosis of cerebral palsy (CP) in preschool-age children (<5y).
Method
Six databases were searched for studies that included a diagnosis of CP validated after 2 years of age. The validity of the studies meeting the criteria was evaluated using the Standards for Reporting Diagnostic Accuracy criteria. Where possible, results were pooled and a meta-analysis was undertaken.
Results
Nineteen out of 351 studies met the full inclusion criteria, including studies of general movements assessment (GMA), cranial ultrasound, brain magnetic resonance imaging (MRI), and neurological examination. All studies assessed high-risk populations including preterm (gestational range 23–41wks) and low-birthweight infants (range 500–4350g). Summary estimates of sensitivity and specificity of GMA were 98% (95% confidence interval [CI] 74–100%) and 91% (95% CI 83–93%) respectively; of cranial ultrasound 74% (95% CI 63–83%) and 92% (95% CI 81–96%) respectively; and of neurological examination 88% (95% CI 55–97%) and 87% (95% CI 57–97%) respectively. MRI performed at term corrected age (in preterm infants) appeared to be a strong predictor of CP, with sensitivity ranging in individual studies from 86 to 100% and specificity ranging from 89 to 97% There was inadequate evidence for the use of other predictive tools.
Summary
This review found that the assessment with the best evidence and strength for predictive accuracy is the GMA. MRI has a good predictive value when performed at term-corrected age. Cranial ultrasound is as specific as MRI and has the advantage of being readily available at the bedside. Studies to date have focused on high-risk infants. The accuracy of these tests in low-risk infants remains unclear and requires further research.read more
Citations
More filters
Journal ArticleDOI
Predictive Value of General Movement Assessment for Cerebral Palsy in Routine Clinical Practice
TL;DR: The risk of motor problems by the age of 2 years increased linearly with the extent of pathological results on the GMA and was 10 times higher when F Ms were absent at 3 months than when FMs were normal.
Journal ArticleDOI
Parental Perspectives on Diagnosis and Prognosis of Neonatal Intensive Care Unit Graduates with Cerebral Palsy.
TL;DR: Clinicians should aim to diagnose CP early and to maintain guarded optimism about future outcomes, as parents remember prognostic discussions about children who develop CP as underestimating functional outcome.
Journal ArticleDOI
General Movements in preterm infants undergoing craniosacral therapy: a randomised controlled pilot-trial
Wolfgang Raith,Peter B. Marschik,Peter B. Marschik,C Sommer,Ute Maurer-Fellbaum,Claudia Amhofer,Alexander Avian,Elisabeth Löwenstein,Susanne Soral,Wilhelm Müller,Christa Einspieler,Berndt Urlesberger +11 more
TL;DR: A group of “healthy” preterm infants undergoing an intervention with craniosacral therapy (IG) showed no significant changes in GMs compared to pre Term infants without intervention (CG), indicating that craniOSacral Therapy seems to be safe in pre term infants.
Journal ArticleDOI
Neurodevelopmental Outcomes Comparing Bevacizumab to Laser for Type 1 ROP.
Sarah Hilkert Rodriguez,Colleen Peyton,Katherine Lewis,Bree Andrews,Mark J. Greenwald,Michael D. Schreiber,Michael E. Msall,Michael P. Blair +7 more
TL;DR: Visual outcomes are an important aspect of neurodevelopment and IVB was not associated with severe developmental disabilities and may protect against vision loss in this analysis, and there were no significant differences in primary outcome measures by treatment group.
Journal ArticleDOI
Community-based parent-delivered early detection and intervention programme for infants at high risk of cerebral palsy in a low-resource country (Learning through Everyday Activities with Parents (LEAP-CP): protocol for a randomised controlled trial.
Katherine A Benfer,Iona Novak,Catherine Morgan,Koa Whittingham,Naila Z. Khan,Robert S. Ware,Kristie L. Bell,Sasaka Bandaranayake,Alison Salt,Asis Kumar Ghosh,Anjan Bhattacharya,Sandip Samanta,Golam Moula,Dilip Bose,Santanu Tripathi,Roslyn N. Boyd +15 more
TL;DR: The primary hypothesis is that infants receiving LEAP-CP will have greater scaled scores on the Pediatric Evaluation of Disability Inventory—Computer Adaptive Test (mobility domain) at 18 months compared with health advice.
References
More filters
Journal ArticleDOI
Development and reliability of a system to classify gross motor function in children with cerebral palsy
Robert J. Palisano,Peter Rosenbaum,Stephen D. Walter,Dianne J Russell,Ellen Wood,Barbara Galuppi +5 more
TL;DR: A five‐level classification system analogous to the staging and grading systems used in medicine, which has application for clinical practice, research, teaching, and administration is developed.
Journal ArticleDOI
A report: the definition and classification of cerebral palsy April 2006.
Peter Rosenbaum,Nigel Paneth,Alan Leviton,Maurice Goldstein,Martin Bax,Diane L. Damiano,Bernard Dan,Bo Jacobsson +7 more
TL;DR: Suggestions were made about the content of a revised definition and classification of CP that would meet the needs of clinicians, investigators, health officials, families and the public and would provide a common language for improved communication.
Journal ArticleDOI
Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers
TL;DR: A network of CP surveys and registers was formed in 14 centres in eight countries across Europe to standardize the definition of CP, inclusion/exclusion criteria, classification, and description of children with CP, and a basis for services planning among European countries.
Journal ArticleDOI
Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative.
Patrick M.M. Bossuyt,Johannes B. Reitsma,David E. Bruns,Constantine Gatsonis,Paul Glasziou,Les Irwig,Jeroen G. Lijmer,David Moher,Drummond Rennie,Henrica C.W. de Vet +9 more
TL;DR: If medical journals adopt the STARD checklist and flow diagram, the quality of reporting of studies of diagnostic accuracy should improve to the advantage of clinicians, researchers, reviewers, journals, and the public.
Journal ArticleDOI
Structural Maturation of Neural Pathways in Children and Adolescents: In Vivo Study
Tomáš Paus,Alex P. Zijdenbos,Keith J. Worsley,D. Louis Collins,Jonathan D. Blumenthal,Jay N. Giedd,Judith L. Rapoport,Alan C. Evans +7 more
TL;DR: Findings provide evidence for a gradual maturation, during late childhood and adolescence, of fiber pathways presumably supporting motor and speech functions.
Related Papers (5)
Early, accurate diagnosis and early intervention in cerebral palsy: Advances in diagnosis and treatment
Iona Novak,Catherine Morgan,Lars Adde,James A Blackman,Roslyn N. Boyd,Janice E. Brunstrom-Hernandez,Giovanni Cioni,Diane L. Damiano,Johanna Darrah,Ann-Christin Eliasson,Linda S. de Vries,Christa Einspieler,Michael T. Fahey,Darcy Fehlings,Donna M. Ferriero,Linda Fetters,Simona Fiori,Hans Forssberg,Andrew M. Gordon,Susan Greaves,Andrea Guzzetta,Mijna Hadders-Algra,Regina T. Harbourne,Angelina Kakooza-Mwesige,Petra Karlsson,Lena Krumlinde-Sundholm,Beatrice Latal,Alison Loughran-Fowlds,Nathalie L. Maitre,Sarah McIntyre,Garey Noritz,Lindsay Pennington,Domenico M. Romeo,Roberta B. Shepherd,Alicia J Spittle,Marelle Thornton,Jane Valentine,Karen Walker,Robert White,Nadia Badawi +39 more