Journal ArticleDOI
ABC transporters as cancer drivers: Potential functions in cancer development.
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TLDR
A more targeted approach of ABC transporters should be implemented that considers which specific transporter is playing a major role in a particular tumour setting in order to achieve a more successful outcome for ABCtransporters inhibitors in cancer therapy.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2019-01-01. It has received 97 citations till now. The article focuses on the topics: ATP-binding cassette transporter.read more
Citations
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The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer.
TL;DR: This review summarizes recent advances that highlight the role of subfamily A members in cancer and links the dispersed knowledge regarding the relationship of ABCA members with lipid metabolism and cancer in an effort to stimulate and guide readers to areas that the writers consider to have significant impact and relevant potentialities.
Journal ArticleDOI
Circular RNAs in drug resistant tumors.
TL;DR: This analysis is expected to provide direction for the prevention and management of drug resistance in tumors and to summarize the up-to-date information regarding the role of circRNAs in the resistance of tumors to chemotherapy.
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TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple.
TL;DR: TRIM11 may be a potential diagnostic marker and therapeutic target for chemoresistant NPC and regulate NPC drug resistance by positively modulating the Daple/β-catenin/ABCC9 signaling pathway.
Journal ArticleDOI
Role of ATP-binding cassette transporters in cancer initiation and progression.
Stefania Nobili,Andrea Lapucci,Ida Landini,Marcella Coronnello,Giandomenico Roviello,Enrico Mini +5 more
TL;DR: Overall, current available information suggests a relevant molecular effector role of some ABC transporters in cancer invasion and metastasis as reported in experimental tumor models.
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The challenge of drug resistance in pancreatic ductal adenocarcinoma: a current overview.
Francisco Quiñonero,Cristina Mesas,Kevin Doello,Laura Cabeza,Gloria Perazzoli,Cristina Jiménez-Luna,Ana R. Rama,Consolación Melguizo,Jose Prados +8 more
TL;DR: Understanding the mechanisms involved in drug resistance will contribute to the development of efficient therapeutic strategies and to improve the prognosis of patients with PDAC.
References
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Journal ArticleDOI
Tissue-based map of the human proteome
Mathias Uhlén,Mathias Uhlén,Linn Fagerberg,Björn M. Hallström,Cecilia Lindskog,Per Oksvold,Adil Mardinoglu,Åsa Sivertsson,Caroline Kampf,Evelina Sjöstedt,Evelina Sjöstedt,Anna Asplund,IngMarie Olsson,Karolina Edlund,Emma Lundberg,Sanjay Navani,Cristina Al-Khalili Szigyarto,Jacob Odeberg,Dijana Djureinovic,Jenny Ottosson Takanen,Sophia Hober,Tove Alm,Per-Henrik Edqvist,Holger Berling,Hanna Tegel,Jan Mulder,Johan Rockberg,Peter Nilsson,Jochen M. Schwenk,Marica Hamsten,Kalle von Feilitzen,Mattias Forsberg,Lukas Persson,Fredric Johansson,Martin Zwahlen,Gunnar von Heijne,Jens Nielsen,Jens Nielsen,Fredrik Pontén +38 more
TL;DR: In this paper, a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level.
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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.
TL;DR: Observations on the molecular basis of pleiotropic drug resistance are interpreted in terms of a model wherein certain surface glycoproteins control drug permeation by modulating the properties of hydrophobic membrane regions.
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A multidrug resistance transporter from human MCF-7 breast cancer cells
L. Austin Doyle,Weidong Yang,Lynne V. Abruzzo,Tammy Krogmann,Y. Gao,Arun K. Rishi,Douglas D. Ross,Douglas D. Ross +7 more
TL;DR: In this article, the authors identify a 2.4-kb mRNA that encodes a 663-aa member of the ATP-binding cassette superfamily of transporters that they termed breast cancer resistance protein (BCRP).
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The Human ATP-Binding Cassette (ABC) Transporter Superfamily
TL;DR: The current knowledge of the human ABC genes, their role in inherited disease, and understanding of the topology of these genes within the membrane are reviewed.
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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
Alexander Greenhough,Helena J M Smartt,Amy E. Moore,Heather R. Roberts,Ann C. Williams,Christos Paraskeva,Abderrahmane Kaidi +6 more
TL;DR: A model for the cellular adaptation to the hypoxic tumour microenvironment that encompasses the interplay between COX-2, hypoxia-inducible factor 1 and dynamic switches in beta-catenin function that fine-tune signalling networks to meet the ever-changing demands of a tumour is proposed.