Journal ArticleDOI
Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson's disease model.
SangMin Kim,Yong Joo Park,Myoung-Sook Shin,Ha Ryong Kim,Min Jae Kim,Sang Hun Lee,Seung Pil Yun,Seung-Hwan Kwon +7 more
TLDR
The results suggest that acacetin is a potent therapeutic agent for PD progression and could inhibit 6-OHDA-induced neuronal cell death originating from ROS-mediated cascade apoptosis pathway.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2017-12-01. It has received 41 citations till now. The article focuses on the topics: Acacetin & Protein kinase B.read more
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Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics.
Mehdi Sharifi-Rad,Chintha Lankatillake,Daniel A. Dias,Anca Oana Docea,Mohamad Fawzi Mahomoodally,Devina Lobine,Paul L. Chazot,Begum Kurt,Tugba Boyunegmez Tumer,Ana Moreira,Farukh Sharopov,Miquel Martorell,Natália Martins,William C. Cho,Daniela Calina,Javad Sharifi-Rad +15 more
TL;DR: The mechanisms of action of some of the major herbal products with potential in the treatment of NDDs are reviewed according to their molecular targets, as well as their regional sources (Asia, America and Africa).
Journal ArticleDOI
Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease.
Subrat Kumar Bhattamisra,Angeline Tzeyung Shak,Lim Wen Xi,Nurul Hasyanazifa Safian,Hira Choudhury,Wei-Meng Lim,Naiyer Shahzad,Nabil A. Alhakamy,Khalid Anwer,Ammu Kutty Radhakrishnan,Shadab +10 more
TL;DR: Results from the animal model of PD show that intranasally-administered RNPs enhanced brain targeting efficiency and drug bioavailability and RNPs for nose-to-brain delivery has significant potential to be developed as a treatment approach for PD.
Journal ArticleDOI
Acacetin, a flavone with diverse therapeutic potential in cancer, inflammation, infections and other metabolic disorders.
TL;DR: Acacetin is a potent molecule reported for its strong anti-inflammatory and anti-cancer activity, however further scientific evidence is essential to validate its potency in disease models associated with inflammation and cancer.
Journal ArticleDOI
Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs
Marianna Tosato,Valerio Di Marco +1 more
TL;DR: The present review reports a list of approximately 800 compounds which have been used, tested or proposed for Parkinson’s disease (PD) therapy in the year range 2014–2019 (April), name(s), chemical structure and references are given.
Journal ArticleDOI
In vitro anti-inflammatory properties of honey flavonoids: A review.
Bibiana Silva,Fabíola Carina Biluca,Luciano Valdemiro Gonzaga,Roseane Fett,Eduardo Monguilhott Dalmarco,Thiago Caon,Ana Carolina Oliveira Costa +6 more
TL;DR: In this paper, in vitro anti-inflammatory properties of flavonoids found in honey were prioritized, and a structure-activity relationship (SAR) was also included to stimulate studies regarding the action of honey in inflammatory events.
References
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The Role of Oxidative Stress in Parkinson’s Disease
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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.
Julie Lotharius,Patrik Brundin +1 more
TL;DR: It is proposed that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease and might represent a common pathway that underlies both genetic and sporadic forms of the disorder.
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Plants and human health in the twenty-first century
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TL;DR: The history, future, scientific background and regulatory issues related to botanical therapeutics, including plant-derived pharmaceuticals, multicomponent botanical drugs, dietary supplements, functional foods and plant-produced recombinant proteins are discussed.