Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics.
Mehdi Sharifi-Rad,Chintha Lankatillake,Daniel A. Dias,Anca Oana Docea,Mohamad Fawzi Mahomoodally,Devina Lobine,Paul L. Chazot,Begum Kurt,Tugba Boyunegmez Tumer,Ana Moreira,Farukh Sharopov,Miquel Martorell,Natália Martins,William C. Cho,Daniela Calina,Javad Sharifi-Rad +15 more
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TLDR
The mechanisms of action of some of the major herbal products with potential in the treatment of NDDs are reviewed according to their molecular targets, as well as their regional sources (Asia, America and Africa).Abstract:
Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.read more
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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.
Mehdi Sharifi-Rad,Nanjangud V. Anil Kumar,Paolo Zucca,Elena Maria Varoni,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Elena Azzini,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,Letizia Polito,Marcello Iriti,Natália Martins,Miquel Martorell,Anca Oana Docea,William N. Setzer,Daniela Calina,William C. Cho,Javad Sharifi-Rad +22 more
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Journal ArticleDOI
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action.
Bahare Salehi,Javad Sharifi-Rad,Francesca Cappellini,Željko Reiner,Debora Zorzan,Muhammad Imran,Bilge Sener,Mehtap Kilic,Mohamed El-Shazly,Mohamed El-Shazly,Nouran M. Fahmy,Eman Al-Sayed,Miquel Martorell,Chiara Tonelli,Katia Petroni,Anca Oana Docea,Daniela Calina,Alfred Maroyi +17 more
TL;DR: An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.
Journal ArticleDOI
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19.
Aristides M. Tsatsakis,Aristides M. Tsatsakis,Daniela Calina,Luca Falzone,Dimitrios Petrakis,Radu Mitrut,Vasileios Siokas,Manuela Pennisi,Giuseppe Lanza,Massimo Libra,Sotirios G. Doukas,Sotirios G. Doukas,Panagiotis G Doukas,Leena Kavali,Amar Bukhari,Chiranjeevi Gadiparthi,Dimitra P. Vageli,Diamantis P. Kofteridis,Demetrios A. Spandidos,Monica Maria Bastos Paoliello,Michael Aschner,Anca Oana Docea +21 more
TL;DR: The present review summarizes the current, though admittedly fluid knowledge on the pathophysiology and symptoms of COVID-19 infection and contributes to a more complete understanding of the disease, and may drive the direction of new research.
Journal ArticleDOI
Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment.
Javad Sharifi-Rad,Cristina Quispe,Monica Butnariu,Lia Sanda Rotariu,Oksana Sytar,Simona Sestito,Simona Sestito,Simona Rapposelli,Simona Rapposelli,Muhammad Akram,Mehwish Iqbal,Akash Krishna,Nanjangud Venkatesh Anil Kumar,Susana S. Braga,Susana M. Cardoso,Karolina Jafernik,Halina Ekiert,Natália Cruz-Martins,Natália Cruz-Martins,Agnieszka Szopa,Marcelo Villagrán,Lorena Mardones,Miquel Martorell,Anca Oana Docea,Daniela Calina +24 more
TL;DR: The use of chitosan-based nanoparticles in nanomedicine, biomedical engineering, discovery and development of new drugs has been discussed in this article, with the focus on properties, usage safety, and potentially valuable applications.
Journal ArticleDOI
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence.
Bahare Salehi,Cristina Quispe,Imane Chamkhi,Nasreddine El Omari,Abdelaali Balahbib,Javad Sharifi-Rad,Abdelhakim Bouyahya,Muhammad Akram,Mehwish Iqbal,Anca Oana Docea,Constantin Caruntu,Gerardo Leyva-Gómez,Abhijit Dey,Miquel Martorell,Daniela Calina,Víctor López,Francisco Les +16 more
TL;DR: In this article, a review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents.
References
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