Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Lakhmir S. Chawla,Rinaldo Bellomo,Azra Bihorac,Stuart L. Goldstein,Edward D. Siew,Sean M. Bagshaw,D B Bittleman,Dinna N. Cruz,Zoltan H. Endre,Robert L. Fitzgerald,Lui G. Forni,Sandra L. Kane-Gill,Eric Hoste,Jay L. Koyner,Kathleen D. Liu,Etienne Macedo,Ravindra L. Mehta,Patrick T. Murray,Mitra K. Nadim,Marlies Ostermann,Paul M. Palevsky,Neesh Pannu,Mitchell H. Rosner,Ron Wald,Alexander Zarbock,Claudio Ronco,John A. Kellum +26 more
TLDR
The Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients, and makes recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.Abstract:
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of >90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.read more
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Global epidemiology and outcomes of acute kidney injury
Eric Hoste,John A. Kellum,Nicholas M. Selby,Alexander Zarbock,Paul M. Palevsky,Sean M. Bagshaw,Stuart L. Goldstein,Jorge Cerdá,Lakhmir S. Chawla +8 more
TL;DR: The global epidemiology of acute kidney injury is described and the influence of modifiable and non-modifiable AKI risk factors, delayed diagnosis, variation in diagnostic criteria and disparities in access to health care are also discussed.
Journal ArticleDOI
Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment.
TL;DR: More mechanistic studies are needed to better understand the convoluted pathophysiology of S-AKI and to translate these findings into potential treatment strategies and add to the promising pharmacologic approaches being developed and tested in clinical trials.
Journal ArticleDOI
Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.
Andrew S. Levey,Kai-Uwe Eckardt,Nijsje M. Dorman,Stacy L. Christiansen,Ewout J. Hoorn,Julie R. Ingelfinger,Lesley A. Inker,Adeera Levin,Rajnish Mehrotra,Paul M. Palevsky,Mark A. Perazella,Mark A. Perazella,Allison Tong,Susan J. Allison,Detlef Bockenhauer,Josephine P. Briggs,Jonathan S. Bromberg,Andrew Davenport,Harold I. Feldman,Denis Fouque,Ron T. Gansevoort,John S. Gill,Eddie L. Greene,Brenda R. Hemmelgarn,Matthias Kretzler,Mark Lambie,Pascale H. Lane,Joseph Laycock,Shari E. Leventhal,Michael Mittelman,Patricia Morrissey,Marlies Ostermann,Lesley Rees,Pierre Ronco,Pierre Ronco,Franz Schaefer,Jennifer St. Clair Russell,Caroline Vinck,Stephen B. Walsh,Daniel E. Weiner,Michael Cheung,Michel Jadoul,Wolfgang C. Winkelmayer +42 more
TL;DR: Recommendations to use "kidney" rather than "renal" or "nephro-" when referring to kidney disease and kidney function and to use the KDIGO definition and classification of chronic kidney disease rather than alternative descriptions to define and classify severity of CKD.
Journal ArticleDOI
Sepsis associated acute kidney injury
Jason T. Poston,Jay L. Koyner +1 more
TL;DR: A growing body of knowledge has illuminated the clinical risk factors, pathobiology, response to treatment, and elements of renal recovery that have advanced the authors' ability to prevent, detect, and treat SA-AKI.
Journal ArticleDOI
Renal recovery after acute kidney injury.
Lui G. Forni,Lui G. Forni,Michael Darmon,Marlies Ostermann,H. M. Oudemans-van Straaten,Ville Pettilä,John R. Prowle,Miet Schetz,Michael Joannidis +8 more
TL;DR: The epidemiology of renal recovery, of the association between AKI and the development of CKD, and the importance of post-discharge follow-up of AKI patients and suggestions for its incorporation into clinical practice are reviewed.
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