Open AccessJournal Article
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling (vol 24, pg 742, 2005)
Karina Reiss,Thorsten Maretzky,Andreas Ludwig,Thomas Tousseyn,B. De Strooper,Dieter H. Hartmann,Paul Saftig +6 more
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This article is published in The EMBO Journal.The article was published on 2005-05-04 and is currently open access. It has received 442 citations till now. The article focuses on the topics: Cadherin & Cleavage (embryo).read more
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Bone-marrow haematopoietic-stem-cell niches
Anne Wilson,Andreas Trumpp +1 more
TL;DR: Recent progress in characterizing the composition of the haematopoietic stem cell bone-marrow microenvironment is reviewed, indicating that future successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem-cell–niche unit.
Journal ArticleDOI
The many faces and functions of β‐catenin
TL;DR: One focus will be the interaction of β‐catenin with different transcription factors and the potential implications of these interactions for direct cross‐talk between β‐ catenin and non‐Wnt signalling pathways.
Journal ArticleDOI
The ADAM metalloproteinases.
TL;DR: The ADAM family are fundamental to many control processes in development and homeostasis, and unsurprisingly they are also linked to pathological states when their functions are dysregulated, including cancer, cardiovascular disease, asthma, Alzheimer’s disease.
Journal ArticleDOI
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
TL;DR: How different members of the cadherin family act in different developmental contexts is examined, and the mechanisms involved are discussed.
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The secretases: enzymes with therapeutic potential in Alzheimer disease
TL;DR: Secretase inhibitors are likely to be the first small-molecule therapies aimed at AD modification that will be fully tested in the clinic and will have enormous consequences for further drug development efforts for AD and possibly other neurodegenerative conditions.
References
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A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
TL;DR: It is shown that siRNA expression mediated by this vector causes efficient and specific down-regulation of gene expression, resulting in functional inactivation of the targeted genes.
Journal ArticleDOI
Identification of c-MYC as a Target of the APC Pathway
Tong-Chuan He,Andrew B. Sparks,Carlo Rago,Heiko Hermeking,Leigh Zawel,Luis T. da Costa,Patrice J. Morin,Bert Vogelstein,Kenneth W. Kinzler +8 more
TL;DR: The c-MYC oncogene is identified as a target gene in this signaling pathway and shown to be repressed by wild-type APC and activated by beta-catenin, and these effects were mediated through Tcf-4 binding sites in the c- MYC promoter.
Journal ArticleDOI
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
TL;DR: A coupling between physical adhesion and developmental signaling provides a mechanism to tightly integrate physical aspects of tissue morphogenesis with cell growth and differentiation, a coordination that is essential to achieve the intricate patterns of cells in tissues.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.
Journal ArticleDOI
Cadherin cell adhesion receptors as a morphogenetic regulator
TL;DR: Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells and play a role in cell sorting mechanisms, conferring adhesion specificities on cells.
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