Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
Reads0
Chats0
TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
Citations
More filters
Journal ArticleDOI
Goal-Directed and Habitual Control in Human Substance Use: State of the Art and Future Directions
Nuria Doñamayor,Claudia Ebrahimi,Viktoria A. Arndt,Franziska Weiss,Florian Schlagenhauf,Tanja Endrass +5 more
TL;DR: Theories of addiction posit a deficit in goal-directed behavior and an increased propensity toward habitual actions in individuals with substance use disorders as mentioned in this paper , and the existing paradigms that aim to evaluate them.
Journal ArticleDOI
Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala.
TL;DR: In this paper, the authors explored ArcN POMC neuronal activation following alcohol consumption to determine whether activation varied within subsets of ArcN pOMC projection neurons targeting different reward-related areas.
Journal ArticleDOI
Could the link between drug addiction in adulthood and substance use in adolescence result from a blurring of the boundaries between incentive and hedonic processes
TL;DR: It is argued that the age of onset is a major risk factor in the development of substance use disorder due to a blurring of the boundaries between incentive and hedonic processes, which occurs during adolescence.
Posted ContentDOI
The Basolateral amygdala → Nucleus Accumbens core circuit mediates the conditioned reinforcing effects of cocaine-paired cues on cocaine seeking
TL;DR: Data demonstrate that the acquisition of cue-controlled cocaine seeking that depends on the conditioned reinforcing effects of cocaine cues require activity in the direct projections from the basolateral amygdala to the nucleus accumbens core.
Intracellular Mechanisms Associated with Cocaine Induced Conditioned Place Preference
TL;DR: Intacellular responses after cocaine-induced conditioned place preference (CPP) in response to two doses of cocaine after reexposure to an environment previously associated with cocaine or a control environment are investigated to suggest that NAc ERK phosphorylation may be involved with retrieving the contextual information of a cocaine-association, without the expression of the behavior.
References
More filters
Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
Journal ArticleDOI
Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.