Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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A wide range of Deep Brain Stimulation of the nucleus accumbens shell time independently reduces the extinction period and prevents the reinstatement of methamphetamine-seeking behavior in rats.
TL;DR: In this paper , the authors investigated the therapeutic effects of NAcSh high- or low-frequency stimulation (HFS or LFS) in the different time points of application on the extinction and reinstatement of the METH-conditioned place preference (CPP).
Posted ContentDOI
Habits are negatively regulated by HDAC3 in the dorsal striatum
Melissa Malvaez,Venuz Y. Greenfield,Dina P. Matheos,Nicolas A. Angelillis,Murphy,Pamela J. Kennedy,Marcelo A. Wood,Kate M. Wassum +7 more
TL;DR: The results challenge the strict dissociation between DMS and DLS function in goal-directed v. habitual behavioral control and identify dorsal striatal HDAC3 as a critical molecular substrate of the transition to habit learning.
Journal ArticleDOI
The Role of Regulation and Emotional Eating Behaviour in the Early Development of Obesity.
Ana V. Valero-Garcia,Marina Olmos-Soria,Julia Madrid-Garrido,Irene Martínez-Hernández,Emma Haycraft +4 more
TL;DR: In this paper, the role of both parents' use of behavioural regulation with food and children's emotional self-regulation in young children with and without overweight/obesity was explored.
Dissertation
Marqueurs comportementaux et neurochimiques individuels de la prise de décision chez la souris et effets d'une dette de sommeil
TL;DR: In this paper, the Mouse Gambling Task (MGT) has been used as a test for prise de decision, based on le test classiquement utilise chez lhomme (l’Iowa Gambling task), which reproduit une situation incertaine, complexe, and conflictuelle de choix.
Journal ArticleDOI
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
TL;DR: In this article , the authors found that compulsive-like alcohol use, operationalized as punishment-resistant self-administration, showed a decrease in dopamine levels restricted to the dorsolateral territories of the striatum, the main output structure of the NE pathway.
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Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.