Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
Citations
More filters
Journal ArticleDOI
Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On
TL;DR: It is hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a Transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum.
Journal ArticleDOI
The dark side of emotion: the addiction perspective.
TL;DR: The thesis argued here is that the brain has specific neurochemical neurocircuitry coded by the hedonic extremes of pleasant and unpleasant emotions that have been identified through the study of opponent processes in the domain of addiction.
Journal ArticleDOI
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction.
TL;DR: The potential for developing treatments for addiction is considered, including the possibility of targeting drug memory reconsolidation and extinction to reduce Pavlovian influences on drug seeking as a means of promoting abstinence and preventing relapse.
Journal ArticleDOI
Dissecting impulsivity and its relationships to drug addictions
J. David Jentsch,James R. Ashenhurst,M. Catalina Cervantes,Stephanie M. Groman,Alex S. James,Zachary T. Pennington +5 more
TL;DR: It is concluded that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption.
Journal ArticleDOI
The transition to compulsion in addiction.
TL;DR: This Review integrates accounts of the neuropharmacological mechanisms that underlie the transition to compulsion with overarching learning theories, to outline how compulsion develops in addiction, highlighting the conceptual distinctions between compulsive drug-seeking behaviour and compulsivedrug-taking behaviour.
References
More filters
Journal ArticleDOI
Drug Abuse: Hedonic Homeostatic Dysregulation
TL;DR: This framework provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and to relapse in individuals with a history of addiction.
Journal ArticleDOI
The debate over dopamine’s role in reward: the case for incentive salience
TL;DR: Dopamine’s contribution appears to be chiefly to cause ‘wanting’ for hedonic rewards, more than ‘liking’ or learning for those rewards.
Journal ArticleDOI
The role of the basal ganglia in habit formation
Henry H. Yin,Barbara J. Knowlton +1 more
TL;DR: Recent work combining modern behavioural assays and neurobiological analysis of the basal ganglia has begun to yield insights into the neural basis of habit formation.
Journal ArticleDOI
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.
TL;DR: An alternative cognitive model of drug use and drug urges is proposed that hypothesizes that drug use in the addict is controlled by automatized action schemata and is implications for the assessment of urge responding and drug-use behavior.
Journal ArticleDOI
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli.
J. D. Jentsch,James Taylor +1 more
TL;DR: The neuro-anatomical and neurochemical substrates subserving inhibitory control and motivational processes in the rodent and primate brain and their putative impact on drug seeking are considered and an integrative hypothesis for compulsive reward-seeking in drug abuse is presented.