Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
Citations
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Journal ArticleDOI
How well do the DSM-5 alcohol use disorder designations map to the ICD-10 disorders?
TL;DR: The DSM-5 and ICD-10 exhibit a high level of agreement for cases that would not receive a diagnosis as well as the most severe cases, however, there are important distinctions to be made between the 2 approaches for mild and moderate DSM disorders in addition to harmful use/misuse cases in the ICD.
Journal ArticleDOI
The Elimination of Abuse and Dependence in DSM-5 Substance Use Disorders: What Does This Mean for Treatment?
TL;DR: The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) marks the beginning of a new chapter in the diagnosis and treatment of substance use disorders as mentioned in this paper.
Journal ArticleDOI
Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior
Nadja Freund,Chloe J. Jordan,Chloe J. Jordan,Jodi L. Lukkes,Kevin J. Norman,Susan L. Andersen +5 more
TL;DR: Sex differences and dose-dependent effects of juvenile exposure to MPH or guanfacine on delay-discounting and later cocaine self-administration are determined and data suggest that MPH is effective in reducing delay discounting in both sexes.
Journal ArticleDOI
Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.
Andry Andrianarivelo,Andry Andrianarivelo,Andry Andrianarivelo,Estefani Saint-Jour,Estefani Saint-Jour,Estefani Saint-Jour,Paula A. Pousinha,Sebastian P. Fernandez,Anna Petitbon,Véronique De Smedt-Peyrusse,Nicolas Heck,Nicolas Heck,Nicolas Heck,Vanesa Ortiz,Marie-Charlotte Allichon,Marie-Charlotte Allichon,Marie-Charlotte Allichon,Vincent Kappes,Vincent Kappes,Vincent Kappes,Sandrine Betuing,Sandrine Betuing,Sandrine Betuing,Roman Walle,Ying Zhu,Charlène Joséphine,Alexis-Pierre Bemelmans,Gustavo Turecki,Naguib Mechawar,Jonathan A. Javitch,Jocelyne Caboche,Jocelyne Caboche,Jocelyne Caboche,Pierre Trifilieff,Jacques Barik,Peter Vanhoutte,Peter Vanhoutte,Peter Vanhoutte +37 more
TL;DR: In this article, the authors showed that drug-evoked heteromerization of glutamate N-methyl-d-aspartate receptors (NMDAR) with dopamine receptor 1 (D1R) or 2 (D2R) occurs in the nucleus accumbens (NAc).
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Negative Urgency Exacerbates Relapse to Cocaine Seeking After Abstinence
TL;DR: In this paper , the authors investigated whether the tendency to relapse depended on the aversive state of withdrawal or instead on the loss of opportunity to perform the ingrained drug-seeking response after periods of abstinence.
References
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Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
Journal ArticleDOI
Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.