Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Generalized habitual tendencies in alcohol dependent rats
Francesco Giannone,Arian Hach,Magdalena Chrószcz,Mario Friske,Marcus W. Meinhardt,Rainer Spanagel,Wolfgang H. Sommer,Anita C. Hansson +7 more
TL;DR: Evidence is provided that a history of alcohol dependence produces a bias towards habitual responding that generalizes to a natural reward in rats, and a habitual bias was induced in non-dependent rats after inactivation of the DMS, thus confirming the critical role of this region in maintaining goal-directed behavior and suggesting its diminished control in AUD.
Journal Article
Compare Rates of Depression in People with Non-dependent and Drug-Dependent which are leaving
TL;DR: Depression severity comparison between the two groups was statistically significant and the severity of depression in patients with substance was more and association between demographic variable education level and employment status, with depression was statistically, significant.
Journal ArticleDOI
Dorsomedial prefrontal cortex activation disrupts Pavlovian incentive motivation
TL;DR: It is found that the dmPFC does not mediate the expression of Pavlovian incentive motivation but instead has the capacity to exert pronounced inhibitory control over this process, suggesting that it is involved in adaptively regulating cue-motivated behavior.
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Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies
Javier Orihuel,Roberto Capellán,David Roura-Martínez,Marcos Ucha,L. Gomez-Rubio,C. Valverde,M. Casquero-Veiga,María Luisa Soto-Montenegro,Manuel Desco,Marta Oteo-Vives,M. Ibanez Moragues,N. Magro-Calvo,Miguel Ángel Morcillo,Emilio Ambrosio,Alejandro Higuera-Matas +14 more
TL;DR: The results suggest that adolescent THC exposure alters psychological and brain development and that the Gateway Hypothesis does not entirely pass the test of preclinical enquiry.
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The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.