Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Réflexion théorique sur la place des mécanismes cognitifs mnésiques et temporels dans l’addiction
TL;DR: In this article, the authors define addictions as a pathologie complexe, sous-tendue par des mecanismes cognitifs en lien avec des anomalies neurobiologiques, which are particulierement importants for the mise en place of l'association substance-contexte, renforcee, par exemple, par le plaisir eprouve lors de la prise de substance (renforcement positif) and par la necessite d'eviter les effets physiques
Journal ArticleDOI
The Effects of Mindfulness Training and Dialectical Behavior Therapy on Drug Craving and Emotion Self-regulation in Clients With Substance-dependence
TL;DR: In this article, a quasi-experimental study with a pre-test, post-test and a control group design was conducted with 60 clients with drug use disorders, willing to participate in the project.
Journal ArticleDOI
Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency.
Eric P. Zorrilla,George F. Koob +1 more
TL;DR: This research presents a novel probabilistic approach to estimating the number of mitochondria in the response of the immune system to certain types of antibiotics.
Book ChapterDOI
Intolerance of uncertainty and addiction
TL;DR: This chapter shows evidence that IU is a key feature of drug addiction, and shows how IU relates to susceptibility to addiction, development and contribution to relapse.
Journal ArticleDOI
Neurochemical substrates linked to impulsive and compulsive phenotypes in addiction: A preclinical perspective.
TL;DR: This article reviewed what is presently known about the neurochemical mediation of impulsivity, in its various forms, and ask whether commonalities exist in the neurochemistry of compulsive drug-motivated behaviours that might explain individual risk for addiction.
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Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
Journal ArticleDOI
Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.