Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
Citations
More filters
Journal ArticleDOI
Pathways to the persistence of drug use despite its adverse consequences.
TL;DR: In this article , the authors review evidence that there are at least three pathways to persistent use despite negative consequences of that use, including a cognitive pathway for recognition of adverse consequences, a motivational pathway for valuation of these consequences and a behavioral pathway for responding to these adverse consequences.
Journal ArticleDOI
G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
Benjamin Galet,M. Ingallinesi,Jonathan Pegon,Anh Do Thi,Philippe Ravassard,Nicole Faucon Biguet,Rolando Meloni +6 more
TL;DR: GPR88 may constitute a highly relevant target for the treatment of the psychiatric symptoms of Parkinson disease, as it efficiently reduced alterations in mood, motivation and cognition through modulation of the regulator of the G-protein signalling 4 and of the truncated splice variant of the FosB transcription factor.
Posted ContentDOI
A whole-brain imaging-based systems approach to understand origin of addiction in binge-like drinking model
Marzena Stefaniuk,Monika Pawłowska,Klaudia Nowicka,Marcin Barański,Zbigniew Zielinski,Łukasz Bijoch,Diana Legutko,Piotr Majka,Sylwia Bednarek,Natalia Jermakow,Daniel K. Wójcik,Leszek Kaczmarek +11 more
TL;DR: In this paper, the authors investigated whole-brain c-Fos expression following reexposure to alcohol in a model of binge-like drinking in mice in IntelliCage.
Journal ArticleDOI
A Systematic Review of Exercise Intervention Program for People With Substance Use Disorder
Zhilei Zhang,Xiujuan Liu +1 more
TL;DR: In this article , a total of 14 randomized controlled experimental literatures on exercise intervention in people with opioid and amphetamine use disorder were screened, the 14 literature included 4 opioids and 10 amphetamines.
References
More filters
Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
Journal ArticleDOI
Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.