Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
Citations
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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On
TL;DR: It is hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a Transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum.
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The dark side of emotion: the addiction perspective.
TL;DR: The thesis argued here is that the brain has specific neurochemical neurocircuitry coded by the hedonic extremes of pleasant and unpleasant emotions that have been identified through the study of opponent processes in the domain of addiction.
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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction.
TL;DR: The potential for developing treatments for addiction is considered, including the possibility of targeting drug memory reconsolidation and extinction to reduce Pavlovian influences on drug seeking as a means of promoting abstinence and preventing relapse.
Journal ArticleDOI
Dissecting impulsivity and its relationships to drug addictions
J. David Jentsch,James R. Ashenhurst,M. Catalina Cervantes,Stephanie M. Groman,Alex S. James,Zachary T. Pennington +5 more
TL;DR: It is concluded that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption.
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The transition to compulsion in addiction.
TL;DR: This Review integrates accounts of the neuropharmacological mechanisms that underlie the transition to compulsion with overarching learning theories, to outline how compulsion develops in addiction, highlighting the conceptual distinctions between compulsive drug-seeking behaviour and compulsivedrug-taking behaviour.
References
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Journal ArticleDOI
The neurocircuitry of impaired insight in drug addiction
Rita Z. Goldstein,A.D. (Bud) Craig,Antoine Bechara,Hugh Garavan,Hugh Garavan,Anna Rose Childress,Martin P. Paulus,Nora D. Volkow +7 more
TL;DR: This perspective with the role of the insula in interoception, self-awareness and drug craving, the anterior cingulate in behavioral monitoring and response selection and drug-related stimuli that predict emotional behavior in addicted individuals are integrated.
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Differential control over cocaine-seeking behavior by nucleus accumbens core and shell.
TL;DR: A neural double-dissociation of the behavioral processes that underlie cocaine self-administration in rats is shown, further understanding of how the NAc controls drug-seeking and drug-taking behavior.
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Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction.
TL;DR: It is suggested that protracted exposure to addictive drugs recruits serial and dopamine-dependent, striato-nigro-striatal ascending spirals from the nucleus accumbens to more dorsal regions of the striatum that underlie a shift from action-outcome to stimulus-response mechanisms in the control over drug seeking.
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Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue.
TL;DR: Results showed a marked increase in DA release in the dorsal striatum during drug-seeking, when cocaine cues were presented contingently, but not when the same cue was presented noncontingently, indicating a possible involvement of the dopaminergic innervation of the dorsal Striatum in well established, or habitual, cocaine-seeking behavior.
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Basolateral Amygdala Neurons Facilitate Reward-Seeking Behavior by Exciting Nucleus Accumbens Neurons
TL;DR: It is shown that BLA input is required for dopamine to enhance the cue-evoked firing of NAc neurons and that this enhanced firing promotes reward-seeking behavior.