Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On
TL;DR: It is hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a Transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum.
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The dark side of emotion: the addiction perspective.
TL;DR: The thesis argued here is that the brain has specific neurochemical neurocircuitry coded by the hedonic extremes of pleasant and unpleasant emotions that have been identified through the study of opponent processes in the domain of addiction.
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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction.
TL;DR: The potential for developing treatments for addiction is considered, including the possibility of targeting drug memory reconsolidation and extinction to reduce Pavlovian influences on drug seeking as a means of promoting abstinence and preventing relapse.
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Dissecting impulsivity and its relationships to drug addictions
J. David Jentsch,James R. Ashenhurst,M. Catalina Cervantes,Stephanie M. Groman,Alex S. James,Zachary T. Pennington +5 more
TL;DR: It is concluded that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption.
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The transition to compulsion in addiction.
TL;DR: This Review integrates accounts of the neuropharmacological mechanisms that underlie the transition to compulsion with overarching learning theories, to outline how compulsion develops in addiction, highlighting the conceptual distinctions between compulsive drug-seeking behaviour and compulsivedrug-taking behaviour.
References
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Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum
TL;DR: Examination of results from multiple tracing experiments simultaneously demonstrates an interface between different striatal regions via the midbrain dopamine cells that forms an ascending spiral between regions that provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain.
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Limbic Activation During Cue-Induced Cocaine Craving
Anna Rose Childress,P. David Mozley,W. Mcelgin,Josh Fitzgerald,Martin Reivich,Charles P. O'Brien +5 more
TL;DR: Findings indicate that limbic activation is one component of cue-induced cocaine craving and may be similarly involved in appetitive craving for other drugs and for natural rewards.
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Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.
TL;DR: Experiments suggest that dopaminergic neurons localized in the posteromedial ventral tegmental area (VTA) and central linear nucleus raphe selectively project to the ventromedial striatum (medial olfactory tubercle and medial nucleus accumbens shell), whereas the anteromedial VTA has few if any projections to the vents of the ventral striatum.
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Addiction and the brain: The neurobiology of compulsion and its persistence
TL;DR: Evidence is reviewed for the possibility that compulsion and its persistence are based on a pathological usurpation of molecular mechanisms that are normally involved in memory, which is often initiated by exposure to drug-related cues.
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Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning.
TL;DR: This study provides direct evidence that the dorsolateral striatum is necessary for habit formation and suggests that, when the habit system is disrupted, control over instrumental performance reverts to the system controlling the performance of goal‐directed instrumental actions.