Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On
TL;DR: It is hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a Transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum.
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The dark side of emotion: the addiction perspective.
TL;DR: The thesis argued here is that the brain has specific neurochemical neurocircuitry coded by the hedonic extremes of pleasant and unpleasant emotions that have been identified through the study of opponent processes in the domain of addiction.
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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction.
TL;DR: The potential for developing treatments for addiction is considered, including the possibility of targeting drug memory reconsolidation and extinction to reduce Pavlovian influences on drug seeking as a means of promoting abstinence and preventing relapse.
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Dissecting impulsivity and its relationships to drug addictions
J. David Jentsch,James R. Ashenhurst,M. Catalina Cervantes,Stephanie M. Groman,Alex S. James,Zachary T. Pennington +5 more
TL;DR: It is concluded that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption.
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The transition to compulsion in addiction.
TL;DR: This Review integrates accounts of the neuropharmacological mechanisms that underlie the transition to compulsion with overarching learning theories, to outline how compulsion develops in addiction, highlighting the conceptual distinctions between compulsive drug-seeking behaviour and compulsivedrug-taking behaviour.
References
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Journal ArticleDOI
Chronic stress causes frontostriatal reorganization and affects decision-making.
Eduardo Dias-Ferreira,Eduardo Dias-Ferreira,Eduardo Dias-Ferreira,João Carlos Sousa,Irene Melo,Pedro Morgado,Ana Mesquita,João José Cerqueira,Rui M. Costa,Rui M. Costa,Nuno Sousa +10 more
TL;DR: It is shown that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences, and the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.
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How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements
TL;DR: By suggesting that the animal learns the overlapping and nested correlations between the stimulus events that commonly occur in a given situation, and by separating what is learned from the processes of response production, the proposed perceptual-motivational framework seems capable of dealing with the problems of motor equivalence and flexibility in adaptive behavior.
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Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum.
David Belin,Barry J. Everitt +1 more
TL;DR: The importance of interactions between ventral and dorsal domains of the striatum, mediated by dopaminergic transmission, in the neural mechanisms underlying the development and performance of cocaine-seeking habits that are a key characteristic of drug addiction is defined.
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Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.
TL;DR: A hypothesis is articulated that altered G protein signaling in the PFC focuses behavior on drug-associated stimuli, while dysregulated PFC-accumbens synaptic glutamate transmission underlies the unmanageable motivation to seek drugs.
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Drug addiction: bad habits add up.
TL;DR: Researchers are addressing the causes of addiction by addressing the brain-learning systems concerned, with the intent of developing better treatments.