Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Opioid receptors: drivers to addiction?
TL;DR: This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether the authors can kill pain without addiction using mu-opioid-receptor-targeting opiates and whether to bridge human and animal opioid research in the field of drug abuse.
Journal ArticleDOI
Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
Christina M. Gremel,Jessica H. Chancey,Brady K. Atwood,Guoxiang Luo,Rachael L. Neve,Charu Ramakrishnan,Karl Deisseroth,David M. Lovinger,Rui M. Costa +8 more
TL;DR: An endogenous molecular mechanism in a specific cortical-striatal pathway that mediates the transition between goal-directed and habitual action strategies is identified and suggests that the emergence of habits depends on endocannabinoid-mediated attenuation of a competing circuit controlling goal- directed behaviors.
Journal ArticleDOI
Heterogeneity of alcohol use disorder: Understanding mechanisms to advance personalized treatment.
TL;DR: Not surprisingly, given its heterogeneity, a wide variety of clinically acceptable treatment outcomes are possible with AUD, including not only abstinence, but also low-risk drinking (and even some less-conservative forms of moderate drinking).
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A multistep general theory of transition to addiction.
Pier Vincenzo Piazza,Pier Vincenzo Piazza,Véronique Deroche-Gamonet,Véronique Deroche-Gamonet +3 more
TL;DR: This general theory demonstrates that drug addiction is a true psychiatric disease caused by a three-step interaction between vulnerable individuals and amount/duration of drug exposure.
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Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model
TL;DR: A novel application of incentive learning theory is proposed which posits that depressed smokers experience greater increases in the expected value of smoking in the face of these three motivational states, which promotes goal-directed choice of smoking behavior over alternative actions.
References
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Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.