Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Electrophysiological signature of the interplay between habits and inhibition in response to smoking‐related cues in individuals with a smoking habit: An event‐related potential study
TL;DR: In this paper , the authors measured the behavioural performance and associated event-related potentials (ERPs) of 20 individuals with a smoking habit and 20 controls, who never smoked regularly, in a modified Go/NoGo task during which smoking-related conditioned stimuli, appetitive and neutral pictures, presented either in first or third-person visual perspective were displayed 250 ms before the cue.
Posted ContentDOI
Mechanism for differential recruitment of orbitostriatal transmission during outcomes and actions in alcohol dependence
Christina M. Gremel,Rafael Renteria,Christian Cazares,Emily T Baltz,Drew C. Schreiner,Ege A Yalcinbas,Thomas Steinkellner,Thomas S. Hnasko +7 more
TL;DR: It is shown that alcohol dependence enhanced activity in OFC terminals in dorsal striatum (OFC-DS) associated with actions, but reduced activity of the same terminals during periods of outcome retrieval, corresponding with a loss of outcome control over decision-making.
Journal ArticleDOI
Global brain c-Fos profiling reveals major functional brain networks rearrangements after alcohol reexposure
Marzena Stefaniuk,Monika Pawłowska,Marcin Barański,K. Nowicka,Z Zieliński,Łukasz Bijoch,Diana Legutko,Piotr Majka,Sylwia Bednarek,Natalia Jermakow,Daniel K. Wójcik,Leszek Kaczmarek +11 more
TL;DR: In this paper , a dedicated image computational workflow was developed to identify c-Fos-positive cells in three-dimensional images obtained after whole-brain optical clearing and imaging in the light-sheet microscope.
Clinical risk factors for substance abuse: The potential effects on treatment outcomes
TL;DR: In this paper, the authors examined the relationship between clinical risk factors for substance abuse and their effects on treatment outcomes and found that needle use, age of first drink, using multiple substances, depression, multiple substance diagnoses, the Big 5 cocaine items (craving, failing to fulfill responsibilities, withdrawal symptoms, giving up pleasant activities to use substances, and inability to reduce or stop substance use), history of substance abuse, as well as all of the behavioral risk items (meeting conduct disorder criteria as an adolescent, being arrested within the past year, and being arrested for a DUI
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Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.