Journal ArticleDOI
Addiction: failure of control over maladaptive incentive habits.
David Belin,Aude Belin-Rauscent,Aude Belin-Rauscent,Jennifer E. Murray,Jennifer E. Murray,Barry J. Everitt,Barry J. Everitt +6 more
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TLDR
It is hypothesized that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-08-01. It has received 232 citations till now. The article focuses on the topics: Addiction & Nucleus accumbens.read more
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Dissertation
Traiter les troubles psychiatriques à l'aide de la stimulation transcrânienne par courant continu : approches comportementale et neurobiologique chez la souris
TL;DR: La stimulation transcrânienne par courant continu (tDCS) est une technique de neuromodulation non invasive qui permet de modifier l'excitabilite co11icale au moyen d'un faible courant electrique delivre a travers le crâne.
Journal ArticleDOI
Checking responses of goal- and sign-trackers are differentially affected by threat in a rodent analog of obsessive–compulsive disorder
TL;DR: A double dissociation in the effects of anxiogenic cues and sensitivity to rewarding stimuli on the propensity to develop functional and dysfunctional checking behavior in a rodent analog of OCD, the observing response task (ORT).
Journal ArticleDOI
Electroencephalography reveals a selective disruption of cognitive control processes in craving cigarette smokers.
Sarah E. Donohue,Sarah E. Donohue,Joseph A. Harris,Joseph A. Harris,Joseph A. Harris,Kristian Loewe,Jens-Max Hopf,Jens-Max Hopf,Hans-Jochen Heinze,Hans-Jochen Heinze,Marty G. Woldorff,Mircea Ariel Schoenfeld,Mircea Ariel Schoenfeld +12 more
TL;DR: Results showed that craving smokers were less flexible with the implementation of cognitive control, with demands of task switching and incongruency yielding greater deficits under conditions of craving.
Journal ArticleDOI
Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour:
Peter van Ruitenbeek,Conny W.E.M. Quaedflieg,Dennis Hernaus,Bart Hartogsveld,Tom Smeets,Tom Smeets +5 more
TL;DR: This paper found that acute stress is thought to reduce goal-directed behavior, an effect purportedly associated with stress-induced release of catecholamines, and experimentally increased systemic systemic...
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Altered mrna levels of stress-related peptides in mouse hippocampus and caudate-putamen in withdrawal after long-term intermittent exposure to tobacco smoke or electronic cigarette vapour
TL;DR: In this article, the authors investigated the alterations in key neurotransmissions after 60 days of withdrawal from seven weeks of intermittent cigarette smoke, e-cigarette vapours, or an E-cigarette vehicle, specifically after cigarette withdrawal in the caudate-putamen nucleus (CPu).
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Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.