Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways.
Manjunath Ramanjaneya,Alex C. Conner,James Brown,Jing Chen,Janet E. Digby,Thomas M. Barber,Hendrik Lehnert,Harpal S. Randeva +7 more
Reads0
Chats0
TLDR
It is demonstrated that stimulation of human adrenocortical H295R cells with adiponectin results in increased cortisol secretion and is accompanied by increased expression of key steroidogenic pathway genes including StAR protein expression via ERK1/2 and AMPK-dependent pathways.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2011-05-01 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Adiponectin receptor 1 & Steroidogenic acute regulatory protein.read more
Citations
More filters
Journal ArticleDOI
The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway.
Zhenling Liu,Jimei Chen,Huang Huanlei,Michelle L. Kuznicki,Shao-yi Zheng,Wanqing Sun,Nanhu Quan,Nanhu Quan,Lin Wang,Lin Wang,Hui Yang,Huiming Guo,Ji Li,Ji Li,Jian Zhuang,Ping Zhu +15 more
TL;DR: The ex vivo working heart perfusion data demonstrated that TMZ treatment significantly activates AMPK signaling and modulating the substrate metabolism by shifting fatty acid oxidation to glucose oxidation during reperfusion, leading to reduction of oxidative stress in the I/R hearts.
OtherDOI
Steroidogenesis-adrenal cell signal transduction.
TL;DR: Many of the aspects addressed in this article still represent a challenge for future studies, their outcome aimed at providing evidence that the adrenal gland, through its steroid hormones, occupies a central position in many situations where homeostasis is disrupted, thus highlighting the relevance of exploring and understanding how this key organ is regulated.
Journal ArticleDOI
Adiponectin Expression in the Porcine Ovary during the Oestrous Cycle and Its Effect on Ovarian Steroidogenesis
Anna Maleszka,Nina Smolinska,Anna Nitkiewicz,Marta Kiezun,Katarzyna Chojnowska,Kamil Dobrzyn,Hubert Szwaczek,Tadeusz Kaminski +7 more
TL;DR: The presence of adiponectin mRNA and protein in the porcine ovary coupled with previous results indicating adip onectin receptors expression suggest that adiponECTin may locally affect ovarian functions.
Journal ArticleDOI
Roles of leptin, adiponectin and resistin in the transcriptional regulation of steroidogenic genes contributing to decreased Leydig cells function in obesity.
Pauline Roumaud,Luc J. Martin +1 more
TL;DR: There are crosstalks between the regulatory mechanisms of these hormones and androgen production which may result in a dramatic negative influence on testosterone plasma levels, which is shown to have a negative impact on testosterone synthesis.
Journal ArticleDOI
Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart.
TL;DR: It is demonstrated that activated protein C (APC) is cardioprotective against ischemia/reperfusion (I/R) injury by augmenting AMPK signaling.
References
More filters
Journal ArticleDOI
A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
Journal ArticleDOI
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Journal ArticleDOI
The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR).
TL;DR: It is demonstrated for the first time that expression of the protein in MA-10 cells in the absence of hormone stimulation is sufficient to induce steroid production and it is proposed that this protein is required in the acute regulation of steroidogenesis.
Journal ArticleDOI
Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.
Dong Lin,Teruo Sugawara,Jerome F. Strauss,Barbara J. Clark,Douglas M. Stocco,Paul Saenger,Alan D. Rogol,Walter L. Miller +7 more
TL;DR: In three unrelated individuals with this disorder, steroidogenic acute regulatory protein, which enhances the mitochondrial conversion of cholesterol into pregnenolone, was mutated and nonfunctional, providing genetic evidence that this protein is indispensable normal adrenal and gonadal steroidogenesis.
Journal ArticleDOI
Multiple Signaling Pathways Regulating Steroidogenesis and Steroidogenic Acute Regulatory Protein Expression: More Complicated than We Thought
TL;DR: The current understanding of additional signaling pathways and factors capable of regulating/modulating steroid hormone biosynthesis, and in many cases steroidogenic acute regulatory protein expression, are discussed in this review.
Related Papers (5)
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Role of adipokines in the control of energy metabolism: focus on adiponectin.
Max Lafontan,Nathalie Viguerie +1 more