Journal ArticleDOI
"ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells.
Yash R. Mehta,Spencer Lewis,Kirby T. Leo,Lihe Chen,Eui-Jung Park,Viswanathan Raghuram,Chung-Lin Chou,Chin-Rang Yang,Hiroaki Kikuchi,Syed J. Khundmiri,Brian G. Poll,Mark A. Knepper +11 more
TLDR
In this paper, a curated list of proteins likely to play roles in determination of cyclic AMP levels in kidney epithelial cells and therefore likely to be determinants of progression of ADPKD was provided.About:
This article is published in Kidney International.The article was published on 2021-10-29. It has received 4 citations till now. The article focuses on the topics: CAMP binding & Biology.read more
Citations
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Journal ArticleDOI
Cilia-Localized Counterregulatory Signals as Drivers of Renal Cystogenesis
Rebecca V Walker,Anthony R. Maranto,Vivek Reddy Palicharla,Sunhee Hwang,Saikat Mukhopadhyay,Feng Qian +5 more
TL;DR: This review discusses the current model of the cilia-dependent cyst activation (CDCA) mechanism in autosomal dominant polycystic kidney disease (ADPKD) and considers the possible roles of ciliary and extraciliary polycystins in regulating CDCA and develops the criteria for cCDCA/CLCI signals.
Journal ArticleDOI
Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation
Kelsey H. Elliott,Sai Keshavan Balchand,C. L. Bonatto Paese,Ching-Fang Chang,Yanfen Yang,Kari M. Brown,Daniel T. Rasicci,Hao He,Konrad Thorner,Praneet Chaturvedi,Stephen A. Murray,Jian Chen,Aleksey Porollo,Kevin A. Peterson,Samantha A. Brugmann +14 more
TL;DR: This article provided a searchable transcriptomic resource for a curated primary ciliome, detailing various subgroups of differentially expressed genes within the Ciliome that display tissue and temporal specificity.
Journal ArticleDOI
Data Resource: Vasopressin-Regulated Protein Phosphorylation Sites in Collecting Duct.
Eui-Yul Park,Chin-Rang Yang,Viswanathan Raghuram,Venkatesh Deshpande,Arnab Kumar Datta,Brian G. Poll,Kirby T. Leo,Hiroaki Kikuchi,Lihe Chen,Chung-Lin Chou,Mark A. Knepper +10 more
TL;DR: A compendium of vasopressin-regulated phosphorylation sites is created with focus on those that are seen in both native rat inner medullary collecting ducts and cultured collecting duct cells from mouse, arguing that these sites are the best candidates for roles in AQP2 regulation.
Journal ArticleDOI
Identification of protein kinase A signalling molecules in renal collecting ducts
TL;DR: In this paper , the authors used immunoprecipitation with antibodies against phosphorylated PKA substrates followed by mass spectrometry analysis revealed that the PKA substrate in proximity to AQP2 was lipopolysaccharide-responsive and beige-like anchor (LRBA).
References
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Journal ArticleDOI
Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology.
TL;DR: This review includes recent discoveries in IC intracellular and paracrine signaling that contributes to acid-base regulation as well as Na+, Cl-, K+, and Ca2+ homeostasis that highlight the potential role of ICs as targets for potential hypertension treatments.
Journal Article
Inhibition of vasopressin-stimulated cyclic AMP accumulation by alpha-2 adrenoceptor agonists in isolated papillary collecting ducts.
R M Edwards,M Gellai +1 more
TL;DR: It is demonstrated that alpha-2 adrenoceptors capable of inhibiting VP action are present on the papillary collecting duct, and the alpha-1 adrenoceptor-induced inhibition of VP-stimulated cAMP accumulation is pertussis-toxin sensitive, which suggests thatalpha-2 Adrenoceptor are coupled negatively to adenylate cyclase, via the guanine nucleotide binding protein, in the collecting tubule.
Journal ArticleDOI
Phosphoproteomic identification of vasopressin V2 receptor-dependent signaling in the renal collecting duct.
Venkatesh Deshpande,Anika R Kao,Viswanathan Raghuram,Arnab Datta,Chung-Lin Chou,Mark A. Knepper +5 more
TL;DR: A comprehensive, multiple-replicate analysis of changes in the phosphoproteome of native rat inner medullary collecting duct cells in response to the V2-selective vasopressin analog dDAVP is carried out to create a web resource for investigation of GPCR signaling and regulation of AQP2-mediated water transport.
Journal ArticleDOI
Primary cilia-regulated transcriptome in the renal collecting duct
Sami G. Mohammed,Francisco J. Arjona,Eric H. J. Verschuren,Zeineb Bakey,Wynand Alkema,Sacha A. F. T. van Hijum,Miriam Schmidts,René J. M. Bindels,Joost G. J. Hoenderop +8 more
TL;DR: This study shows that the involvement of primary cilia in ion transport in the collecting duct is exceptionally specific and validated by quantitative real‐time PCR.
Journal ArticleDOI
Targeting chloride transport in autosomal dominant polycystic kidney disease.
TL;DR: The studies of fluid and chloride transport in ADPKD paved the way for innovative therapeutic targets to prevent cyst volume expansion and thus, kidney disease progression.