Journal ArticleDOI
"ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells.
Yash R. Mehta,Spencer Lewis,Kirby T. Leo,Lihe Chen,Eui-Jung Park,Viswanathan Raghuram,Chung-Lin Chou,Chin-Rang Yang,Hiroaki Kikuchi,Syed J. Khundmiri,Brian G. Poll,Mark A. Knepper +11 more
TLDR
In this paper, a curated list of proteins likely to play roles in determination of cyclic AMP levels in kidney epithelial cells and therefore likely to be determinants of progression of ADPKD was provided.About:
This article is published in Kidney International.The article was published on 2021-10-29. It has received 4 citations till now. The article focuses on the topics: CAMP binding & Biology.read more
Citations
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Journal ArticleDOI
Cilia-Localized Counterregulatory Signals as Drivers of Renal Cystogenesis
Rebecca V Walker,Anthony R. Maranto,Vivek Reddy Palicharla,Sunhee Hwang,Saikat Mukhopadhyay,Feng Qian +5 more
TL;DR: This review discusses the current model of the cilia-dependent cyst activation (CDCA) mechanism in autosomal dominant polycystic kidney disease (ADPKD) and considers the possible roles of ciliary and extraciliary polycystins in regulating CDCA and develops the criteria for cCDCA/CLCI signals.
Journal ArticleDOI
Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation
Kelsey H. Elliott,Sai Keshavan Balchand,C. L. Bonatto Paese,Ching-Fang Chang,Yanfen Yang,Kari M. Brown,Daniel T. Rasicci,Hao He,Konrad Thorner,Praneet Chaturvedi,Stephen A. Murray,Jian Chen,Aleksey Porollo,Kevin A. Peterson,Samantha A. Brugmann +14 more
TL;DR: This article provided a searchable transcriptomic resource for a curated primary ciliome, detailing various subgroups of differentially expressed genes within the Ciliome that display tissue and temporal specificity.
Journal ArticleDOI
Data Resource: Vasopressin-Regulated Protein Phosphorylation Sites in Collecting Duct.
Eui-Yul Park,Chin-Rang Yang,Viswanathan Raghuram,Venkatesh Deshpande,Arnab Kumar Datta,Brian G. Poll,Kirby T. Leo,Hiroaki Kikuchi,Lihe Chen,Chung-Lin Chou,Mark A. Knepper +10 more
TL;DR: A compendium of vasopressin-regulated phosphorylation sites is created with focus on those that are seen in both native rat inner medullary collecting ducts and cultured collecting duct cells from mouse, arguing that these sites are the best candidates for roles in AQP2 regulation.
Journal ArticleDOI
Identification of protein kinase A signalling molecules in renal collecting ducts
TL;DR: In this paper , the authors used immunoprecipitation with antibodies against phosphorylated PKA substrates followed by mass spectrometry analysis revealed that the PKA substrate in proximity to AQP2 was lipopolysaccharide-responsive and beige-like anchor (LRBA).
References
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Journal ArticleDOI
Inhibition by epinephrine of AVP- and cAMP-stimulated Na+ and water transport in Dahl rat CCD.
TL;DR: It is concluded that epinephrine acts via an alpha 2-receptor to inhibit adenylate cyclase but that at least one additional intracellular second messenger system may be involved.
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Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
Jan N. Hansen,Fabian Kaiser,Christina Klausen,Birthe Stüven,Raymond Chong,Wolfgang Bönigk,David U. Mick,Andreas Möglich,Nathalie Jurisch-Yaksi,Florian I. Schmidt,Dagmar Wachten,Dagmar Wachten +11 more
TL;DR: A nanobody-based targeting approach for optogenetic tools in mammalian cells and in vivo in zebrafish to specifically analyze ciliary signaling and function is described and overcome the loss of protein function observed after fusion to ciliary targeting sequences.
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Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells
Mollisa M. Elrick,Willis K. Samson,John A. Corbett,Alison S. Salvatori,Lauren M. Stein,Grant R. Kolar,Aaron Naatz,Gina L. C. Yosten +7 more
TL;DR: It is demonstrated that NST increases proglucagon message in α-cells and a potential mechanism for NST's cellular activities, including the phosphorylation of PKA following activation of the G protein-coupled receptor, GPR107 is identified.
Journal ArticleDOI
From Molecules to Mechanisms: Functional Proteomics and Its Application to Renal Tubule Physiology
TL;DR: The application of proteomics to study the regulation of kidney function has yielded novel insights into the chemical and physical processes that tightly control body fluids, electrolytes, and metabolites to provide optimal microenvironments for various cellular and organ functions.
Journal ArticleDOI
Generation and phenotypic characterization of Pde1a mutant mice.
Xiaofang Wang,Satsuki Yamada,Wells B. LaRiviere,Hong Ye,Jason L. Bakeberg,Maria V. Irazabal,Fouad T. Chebib,Jan M. van Deursen,Peter C. Harris,Caroline R. Sussman,Atta Behfar,Christopher J. Ward,Vicente E. Torres +12 more
TL;DR: An important role of PDE1A in the renal pathogenesis of ADPKD and in the regulation of blood pressure is supported.