Journal ArticleDOI
"ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells.
Yash R. Mehta,Spencer Lewis,Kirby T. Leo,Lihe Chen,Eui-Jung Park,Viswanathan Raghuram,Chung-Lin Chou,Chin-Rang Yang,Hiroaki Kikuchi,Syed J. Khundmiri,Brian G. Poll,Mark A. Knepper +11 more
TLDR
In this paper, a curated list of proteins likely to play roles in determination of cyclic AMP levels in kidney epithelial cells and therefore likely to be determinants of progression of ADPKD was provided.About:
This article is published in Kidney International.The article was published on 2021-10-29. It has received 4 citations till now. The article focuses on the topics: CAMP binding & Biology.read more
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Journal ArticleDOI
Cilia-Localized Counterregulatory Signals as Drivers of Renal Cystogenesis
Rebecca V Walker,Anthony R. Maranto,Vivek Reddy Palicharla,Sunhee Hwang,Saikat Mukhopadhyay,Feng Qian +5 more
TL;DR: This review discusses the current model of the cilia-dependent cyst activation (CDCA) mechanism in autosomal dominant polycystic kidney disease (ADPKD) and considers the possible roles of ciliary and extraciliary polycystins in regulating CDCA and develops the criteria for cCDCA/CLCI signals.
Journal ArticleDOI
Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation
Kelsey H. Elliott,Sai Keshavan Balchand,C. L. Bonatto Paese,Ching-Fang Chang,Yanfen Yang,Kari M. Brown,Daniel T. Rasicci,Hao He,Konrad Thorner,Praneet Chaturvedi,Stephen A. Murray,Jian Chen,Aleksey Porollo,Kevin A. Peterson,Samantha A. Brugmann +14 more
TL;DR: This article provided a searchable transcriptomic resource for a curated primary ciliome, detailing various subgroups of differentially expressed genes within the Ciliome that display tissue and temporal specificity.
Journal ArticleDOI
Data Resource: Vasopressin-Regulated Protein Phosphorylation Sites in Collecting Duct.
Eui-Yul Park,Chin-Rang Yang,Viswanathan Raghuram,Venkatesh Deshpande,Arnab Kumar Datta,Brian G. Poll,Kirby T. Leo,Hiroaki Kikuchi,Lihe Chen,Chung-Lin Chou,Mark A. Knepper +10 more
TL;DR: A compendium of vasopressin-regulated phosphorylation sites is created with focus on those that are seen in both native rat inner medullary collecting ducts and cultured collecting duct cells from mouse, arguing that these sites are the best candidates for roles in AQP2 regulation.
Journal ArticleDOI
Identification of protein kinase A signalling molecules in renal collecting ducts
TL;DR: In this paper , the authors used immunoprecipitation with antibodies against phosphorylated PKA substrates followed by mass spectrometry analysis revealed that the PKA substrate in proximity to AQP2 was lipopolysaccharide-responsive and beige-like anchor (LRBA).
References
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Journal ArticleDOI
Dynamics connect substrate recognition to catalysis in protein kinase A
Larry R. Masterson,Cecilia Y. Cheng,Tao Yu,Marco Tonelli,Alexandr P. Kornev,Susan S. Taylor,Gianluigi Veglia +6 more
TL;DR: The results show that the enzyme toggles between open and closed states, which indicates that a conformational selection rather than an induced-fit mechanism governs substrate recognition.
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Molecular Characterization of a Second Mouse Pancreatic Polypeptide Receptor and Its Inactivated Human Homologue
TL;DR: Cloned PP2 suggests that in mouse there are at least two PP receptors, Y4/PP1 and PP2, whereas in humans, PP2 is either functionally inactive or it has acquired a PP-independent function.
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PTH sensitive adenyl cyclase activity in different segments of the rabbit nephron.
TL;DR: It is concluded that in addition to PCT and PR, CAL and BCT might be target structures involved in the physiological actions of PTH on the kidney.
Journal ArticleDOI
Interaction between RGS7 and polycystin
Emily Kim,Thierry Arnould,Lorenz Sellin,Thomas Benzing,N. Comella,Olivier Kocher,Leonidas Tsiokas,Vikas P. Sukhatme,Gerd Walz +8 more
TL;DR: The identified a short-lived RGS protein, RGS7, that is rapidly degraded through the proteasome pathway and interaction with integral membrane proteins are potential means of regulating RGS proteins.
Journal ArticleDOI
Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor–dependent signaling pathways in renal collecting duct cells
Markus M. Rinschen,Ming-Jiun Yu,Guanghui Wang,Emily S. Boja,Jason D. Hoffert,Trairak Pisitkun,Mark A. Knepper +6 more
TL;DR: The data support roles for multiple vasopressin V2-receptor–dependent signaling pathways in the vasoppressin signaling network of collecting duct cells, involving several kinases not generally accepted to regulate collecting duct function.