Journal ArticleDOI
Advanced methodologies for cocrystal synthesis.
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TLDR
This review summarizes recent trends and advances in synthesis, manufacturing and scale – up of cocrystals including their advantages and disadvantages in terms of crystal quality, purity stability, throughput and limitations in large scale production.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2017-08-01. It has received 135 citations till now.read more
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Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela,Miguel Rodrigues,Andreia Duarte,Ana M.A. Dias,Mara E.M. Braga,Hermínio C. de Sousa +5 more
TL;DR: A comprehensive state‐of‐the‐art review on scCO2‐based processes focused on the formation and on the control of the physicochemical, structural and morphological properties of amorphous/crystalline pure drug nanoparticles.
Journal ArticleDOI
Production of pure drug nanocrystals and nano co-crystals by confinement methods.
TL;DR: This review analyzes the processes for the preparation of nanocrystals and co‐crystals, divided by top‐down and bottom‐up approaches, together with their combinations and concludes that the combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes.
Journal ArticleDOI
Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs
TL;DR: A review on various applications of pharmaceutical cocrystallization with considerations on both cocrystals and salts, focusing on the property modification relevant to clinical efficacy and safety, and manufacturability of drugs is presented in this article.
Journal ArticleDOI
Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing
Adam A. L. Michalchuk,Adam A. L. Michalchuk,Adam A. L. Michalchuk,Karl S. Hope,Stuart R. Kennedy,Maria Valeria Blanco,Elena V. Boldyreva,Colin R. Pulham,Colin R. Pulham +8 more
TL;DR: The first in situ study of RAM-induced co-crystallisation monitored using synchrotron X-ray powder diffraction is presented, providing new insight into the role of various experimental parameters in conventional mechanochemistry using liquid-assisted grinding techniques.
Journal ArticleDOI
Recent advances in improving oral drug bioavailability by cocrystals.
TL;DR: There are remaining challenges on safety, predicting in vivo behavior and revealing real potential of cocrystals in the human, which should be taken into account when conducting bioavailability studies.
References
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Journal ArticleDOI
Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?
TL;DR: The evolution of crystal engineering into a form of supramolecular synthesis is discussed in this article in the context of problems and opportunities in the pharmaceutical industry, and it has become clear that a wide array of multiple component pharmaceutical phases, so called pharmaceutical co-crystals, can be rationally designed using crystal engineering, and the strategy affords new intellectual property and enhanced properties for pharmaceutical substances.
Journal ArticleDOI
Hallmarks of mechanochemistry: From nanoparticles to technology
Peter Baláž,Marcela Achimovičová,Matej Baláž,P. Billik,P. Billik,Zara Cherkezova-Zheleva,José M. Criado,Francesco Delogu,Erika Dutková,Eric Gaffet,Francisco J. Gotor,Rakesh Kumar,Ivan Mitov,Tadej Rojac,Mamoru Senna,A. N. Streletskii,A. N. Streletskii,Krystyna Wieczorek-Ciurowa +17 more
TL;DR: The aim of this review article is to provide a comprehensive overview of advances achieved in the field of atomistic processes, phase transformations, simple and multicomponent nanosystems and peculiarities of mechanochemistry.
Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Polymorphs, Salts, and Cocrystals: What’s in a Name?
Srinivasulu Aitipamula,Rahul Banerjee,Arvind K. Bansal,Kumar Biradha,Miranda L. Cheney,Angshuman Roy Choudhury,Gautam R. Desiraju,Amol G. Dikundwar,Ritesh Dubey,Naga Kiran Duggirala,Preetam P. Ghogale,Soumyajit Ghosh,Pramod Kumar Goswami,N. Rajesh Goud,Ram K. R. Jetti,Piotr H. Karpinski,Poonam Kaushik,Dinesh Kumar,Vineet Kumar,Brian Moulton,Arijit Mukherjee,Gargi Mukherjee,Allan S. Myerson,Vibha Puri,Arunachalam Ramanan,T. Rajamannar,C. Malla Reddy,Naír Rodríguez-Hornedo,Robin D. Rogers,T. N. Guru Row,Palash Sanphui,Ning Shan,Ganesh Shete,Amit Singh,Changquan Calvin Sun,Jennifer A. Swift,Ram Thaimattam,Tejender S. Thakur,Rajesh Kumar Thaper,Sajesh P. Thomas,Srinu Tothadi,Venu R. Vangala,Narayan Variankaval,Peddy Vishweshwar,David R. Weyna,Michael J. Zaworotko +45 more
TL;DR: A discussion of the FDA guidance on regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) was held in Manesar near Delhi, India, from February 2-4, 2012 as mentioned in this paper.
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Polymorphs, Salts, and Cocrystals: What’s in a Name?
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