Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization.
Tao Zuo,Fen Zhang,Grace Lui,Yun Kit Yeoh,Amy Li,Hui Zhan,Yating Wan,Arthur C.K. Chung,Chun Pan Cheung,Nan Chen,Christopher K C Lai,Zigui Chen,Eugene Y.K. Tso,Kitty S. C. Fung,Veronica L. Chan,Lowell Ling,Gavin M. Joynt,David S.C. Hui,Francis K.L. Chan,Paul K.S. Chan,Siew C. Ng +20 more
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TLDR
Fecal microbiota alterations were associated with fecal levels of SARS-CoV-2 and COVID-19 severity, and strategies to alter the intestinal microbiota might reduce disease severity.About:
This article is published in Gastroenterology.The article was published on 2020-09-01 and is currently open access. It has received 961 citations till now. The article focuses on the topics: Bacteroides thetaiotaomicron & Bacteroides dorei.read more
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Post-acute COVID-19 syndrome.
Ani Nalbandian,Kartik Sehgal,Kartik Sehgal,Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Claire McGroder,Jacob S. Stevens,Joshua R. Cook,Anna S. Nordvig,Daniel Shalev,Tejasav S. Sehrawat,Neha Ahluwalia,Behnood Bikdeli,Donald Dietz,Caroline Der-Nigoghossian,Nadia Liyanage-Don,Gregg F. Rosner,Elana J. Bernstein,Sumit Mohan,Akinpelumi A Beckley,David S. Seres,Toni K. Choueiri,Toni K. Choueiri,Nir Uriel,John C. Ausiello,Domenico Accili,Daniel E. Freedberg,Matthew R. Baldwin,Allan Schwartz,Daniel Brodie,Christine Kim Garcia,Mitchell S.V. Elkind,Jean M. Connors,Jean M. Connors,John P. Bilezikian,Donald W. Landry,Elaine Wan +37 more
TL;DR: A comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae is provided in this paper, where the authors discuss relevant considerations for the multidisciplinary care of COPD survivors and propose a framework for the identification of those at high risk for COPD and their coordinated management through dedicated COPD clinics.
Journal ArticleDOI
Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19.
Yun Kit Yeoh,Tao Zuo,Grace Lui,Fen Zhang,Qin Liu,Amy Li,Arthur C.K. Chung,Chun Pan Cheung,Eugene Y.K. Tso,Kitty S. C. Fung,Veronica L. Chan,Lowell Ling,Gavin M. Joynt,David S.C. Hui,Kai Ming Chow,Susanna So Shan Ng,Timothy Li,Rita W Y Ng,Terry Cheuk-Fung Yip,Grace Lai-Hung Wong,Francis K.L. Chan,Chun K. Wong,Paul K.S. Chan,Siew C. Ng +23 more
TL;DR: In this article, the authors investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.
Journal ArticleDOI
Long covid-mechanisms, risk factors, and management.
TL;DR: In this article, a review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure, including fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of posttraumatic stress disorder, muscle pain, concentration problems, and headache.
Journal ArticleDOI
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments.
TL;DR: In this paper, a review of the literature on long COVID-19 syndrome is presented, which is driven by long-term tissue damage (e.g. lung, brain, and heart) and pathological inflammation (i.e. from viral persistence, immune dysregulation, and autoimmunity).
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Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections.
Petra Zimmermann,Nigel Curtis +1 more
TL;DR: Factors that might protect children include differences in innate and adaptive immunity, more frequent recurrent and concurrent infections, pre-existing immunity to coronaviruses, and differences in microbiota.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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Microbial ecology: Human gut microbes associated with obesity
TL;DR: It is shown that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet.
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