Alzheimer's disease as homeostatic responses to age-related myelin breakdown
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This work delineates empirically testable mechanisms of action for genes underlying FAD and LOAD and provides "upstream" treatment targets and reframes key observations such as axonal transport disruptions, formation of axonal swellings/sphenoids and neuritic plaques, and proteinaceous deposits as by-products of homeostatic myelin repair processes.Citations
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The connectomics of brain disorders
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The Cellular Phase of Alzheimer’s Disease
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Intramuscular desferrioxamine in patients with Alzheimer's disease
TL;DR: In this paper, a single-blind study was conducted to investigate whether the progression of dementia could be slowed by the trivalent ion chelator, desferrioxamine.
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White matter characterization with diffusional kurtosis imaging.
TL;DR: A physically meaningful interpretation of DKI metrics in white matter regions consisting of more or less parallel aligned fiber bundles is provided by modeling the tissue as two non-exchanging compartments, the intra-axonal space and extra-AXonal space.
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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
References
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Book ChapterDOI
Structural changes in the normally aging cerebral cortex of primates.
TL;DR: It is now known that cognitive decline in human and nonhuman primates is not due to loss of cortical neurons and there is no correlation between the frequency of senile plaques and cognitive status.
Journal ArticleDOI
γ-Secretase Substrate Concentration Modulates the Aβ42/Aβ40 Ratio IMPLICATIONS FOR ALZHEIMER DISEASE
TL;DR: In this article, the reaction mechanism of γ-secretase with wild type and three mutated APP substrates was determined, and it was shown that biological factors affecting targets such as BACE1 and APP can augment the Aβ42/Aβ40 ratio and may play a causative role in sporadic AD.
Journal ArticleDOI
Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study.
George Bartzokis,George Bartzokis,Keith H. Nuechterlein,Po-Haong Lu,Po-Haong Lu,Michael J. Gitlin,Steven Rogers,Jim Mintz,Jim Mintz +8 more
TL;DR: Differences in gray to white matter ratio between the groups increased markedly with age, driven primarily by the absence of a white matter volume expansion in the patient group, suggesting this dynamic developmental process is dysregulated in adult schizophrenic subjects.
Journal ArticleDOI
Parameters related to lipid metabolism as markers of myelination in mouse brain
TL;DR: It is concluded that measurement of cerebroside synthesis rates provides a good measure of the rate of myelination, and may be useful as an additional parameter for examining the effects of environmental or genetic alterations on the Rate of Myelination.
Journal ArticleDOI
Uptake of lipoproteins for axonal growth of sympathetic neurons.
TL;DR: It is demonstrated for the first time that lipids are taken up from lipoproteins by sympathetic neurons for use in axonal regeneration.