Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Reads0
Chats0
TLDR
This work delineates empirically testable mechanisms of action for genes underlying FAD and LOAD and provides "upstream" treatment targets and reframes key observations such as axonal transport disruptions, formation of axonal swellings/sphenoids and neuritic plaques, and proteinaceous deposits as by-products of homeostatic myelin repair processes.Citations
More filters
Journal ArticleDOI
The connectomics of brain disorders
TL;DR: This work considers how brain-network topology shapes neural responses to damage, highlighting key maladaptive processes and the resources and processes that enable adaptation, and shows how knowledge of network topology allows for predictive models of the spread and functional consequences of brain disease.
Journal ArticleDOI
The Cellular Phase of Alzheimer’s Disease
TL;DR: Evidence supporting a long, complex cellular phase consisting of feedback and feedforward responses of astrocytes, microglia, and vasculature is reviewed.
Journal Article
Intramuscular desferrioxamine in patients with Alzheimer's disease
TL;DR: In this paper, a single-blind study was conducted to investigate whether the progression of dementia could be slowed by the trivalent ion chelator, desferrioxamine.
Journal ArticleDOI
White matter characterization with diffusional kurtosis imaging.
TL;DR: A physically meaningful interpretation of DKI metrics in white matter regions consisting of more or less parallel aligned fiber bundles is provided by modeling the tissue as two non-exchanging compartments, the intra-axonal space and extra-AXonal space.
Journal ArticleDOI
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
References
More filters
Journal ArticleDOI
Recent advances in brain cholesterol dynamics : transport, domains, and alzheimer's disease
W. Gibson Wood,W. Gibson Wood,Friedhelm Schroeder,Nicolai A. Avdulov,Nicolai A. Avdulov,Svetlana V. Chochina,Svetlana V. Chochina,Urule Igbavboa,Urule Igbavboa +8 more
TL;DR: Recent contributions to the understanding of brain cholesterol dynamics are examined, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.
Journal ArticleDOI
BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.
Dione Kobayashi,Michelle Zeller,Tracy Cole,Manuel Buttini,Lisa McConlogue,Sukanto Sinha,Stephen B. Freedman,Richard G. M. Morris,Karen S. Chen +8 more
TL;DR: Results suggest that while excess Abeta is functionally pathological, BACE1-mediated processing of APP and other substrates play a role in "normal" learning, memory and sensorimotor processes.
Journal ArticleDOI
Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells: POSSIBLE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ (PPARγ) IN THE PATHOGENESIS OF HUNTINGTON DISEASE*
TL;DR: Evidence indicates that PPARγ activation by rosiglitazone attenuates mitochondrial dysfunction in mutant huntingtin-expressing striatal cells, and this could be an important therapeutic avenue to ameliorate the mitochondrial dysfunction that occurs in HD.
Journal ArticleDOI
Serotonin stimulates mitochondrial transport in hippocampal neurons
TL;DR: It is shown that the neuromodulator serotonin (5-HT) greatly enhances mitochondrial movement in the axons of rat hippocampal neurons in vitro and suggests that 5-HT may mediate the redistribution of energy sources within responsive neurons.
Journal ArticleDOI
Insulin-like growth factor I (IGF-I) and cognitive decline in older persons.
TL;DR: It is suggested that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed.